Horner David, Jepsen Jens Richardt M, Chawes Bo, Aagaard Kristina, Rosenberg Julie B, Mohammadzadeh Parisa, Sevelsted Astrid, Vahman Nilo, Vinding Rebecca, Fagerlund Birgitte, Pantelis Christos, Bilenberg Niels, Pedersen Casper-Emil T, Eliasen Anders, Brandt Sarah, Chen Yulu, Prince Nicole, Chu Su H, Kelly Rachel S, Lasky-Su Jessica, Halldorsson Thorhallur I, Strøm Marin, Strandberg-Larsen Katrine, Olsen Sjurdur F, Glenthøj Birte Y, Bønnelykke Klaus, Ebdrup Bjørn H, Stokholm Jakob, Rasmussen Morten Arendt
COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark.
Center for Neuropsychiatric Schizophrenia Research (CNSR) and Centre for Clinical Intervention and Neuropsychiatric Schizophrenia Research (CINS), Mental Health Centre Glostrup, University of Copenhagen, Glostrup, Denmark.
Nat Metab. 2025 Mar;7(3):586-601. doi: 10.1038/s42255-025-01230-z. Epub 2025 Mar 3.
Despite the high prevalence of neurodevelopmental disorders, the influence of maternal diet during pregnancy on child neurodevelopment remains understudied. Here we show that a western dietary pattern during pregnancy is associated with child neurodevelopmental disorders. We analyse self-reported maternal dietary patterns at 24 weeks of pregnancy and clinically evaluated neurodevelopmental disorders at 10 years of age in the COPSAC2010 cohort (n = 508). We find significant associations with attention-deficit hyperactivity disorder (ADHD) and autism diagnoses. We validate the ADHD findings in three large, independent mother-child cohorts (n = 59,725, n = 656 and n = 348) through self-reported dietary modelling, maternal blood metabolomics and foetal blood metabolomics. Metabolome analyses identify 15 mediating metabolites in pregnancy that improve ADHD prediction. Longitudinal blood metabolome analyses, incorporating five time points per cohort in two independent cohorts, reveal that associations between western dietary pattern metabolite scores and neurodevelopmental outcomes are consistently significant in early-mid-pregnancy. These findings highlight the potential for targeted prenatal dietary interventions to prevent neurodevelopmental disorders and emphasise the importance of early intervention.
尽管神经发育障碍的患病率很高，但孕期母亲饮食对儿童神经发育的影响仍未得到充分研究。在此，我们表明孕期西方饮食模式与儿童神经发育障碍有关。我们分析了COPSAC2010队列（n = 508）中孕妇在妊娠24周时自我报告的饮食模式以及10岁时临床评估的神经发育障碍情况。我们发现与注意力缺陷多动障碍（ADHD）和自闭症诊断存在显著关联。我们通过自我报告的饮食建模、母亲血液代谢组学和胎儿血液代谢组学，在三个大型独立母婴队列（n = 59,725、n = 656和n = 348）中验证了ADHD的研究结果。代谢组分析确定了孕期15种介导代谢物，可改善ADHD预测。纵向血液代谢组分析在两个独立队列中每个队列纳入五个时间点，结果显示西方饮食模式代谢物评分与神经发育结局之间的关联在妊娠早中期始终显著。这些发现突出了针对性产前饮食干预预防神经发育障碍的潜力，并强调了早期干预的重要性。
