Macbeth Fergus R, Abratt Raymond P, Cho Kwan H, Stephens Richard J, Jeremic Branislav
National Collaborating Centre for Cancer, Cardiff, UK.
Radiother Oncol. 2007 Feb;82(2):123-31. doi: 10.1016/j.radonc.2006.12.006. Epub 2007 Jan 19.
Lung cancer is a major cause of cancer death worldwide and is becoming an increasing problem in developing countries. It is important that, in countries where health care resources are limited, these resources are used most effectively and cost-effectively. The authors, with the support of the International Atomic Energy Agency, drew on existing evidence-based clinical guidelines, published systematic reviews and meta-analyses, as well as recent research publications, to summarise the current evidence and to make broad recommendations on the non-surgical treatment of patients with lung cancer. Tables were constructed which summarise the different treatment options for specific groups of patients, the increase in resource use for and the likely additional clinical benefit from each option. These tables can be used to assess the cost-effectiveness and appropriateness of different interventions in a particular health care system and to develop local clinical guidelines.
肺癌是全球癌症死亡的主要原因,并且在发展中国家正成为一个日益严重的问题。在医疗保健资源有限的国家,有效且经济高效地利用这些资源非常重要。作者在国际原子能机构的支持下,借鉴现有的循证临床指南、已发表的系统评价和荟萃分析以及近期的研究出版物,总结当前证据,并就肺癌患者的非手术治疗提出广泛建议。构建了表格,总结了特定患者群体的不同治疗选择、每种选择的资源使用增加情况以及可能的额外临床益处。这些表格可用于评估特定医疗保健系统中不同干预措施的成本效益和适宜性,并制定当地的临床指南。