Tarpila E, Nyström P O, Ihse I
Department of Surgery, Linköping University, Lund, Sweden.
Int J Pancreatol. 1991 Nov-Dec;10(3-4):229-36. doi: 10.1007/BF02924160.
The resorption from the peritoneum of fluorescein-isothiocyanate-conjugated (FITC) dextran with a mol wt of 10,000 was studied after 6, 15, and 24 h in rats with (1) only laparotomy (LC), (2) bacterial peritonitis (BP), (3) bile-induced acute pancreatitis (AP), (4) acute pancreatitis induced with contaminated bile (AIP), and (5) cerulein administration during acute pancreatitis (CAP). Animals in the AIP and CAP groups had a significantly higher mortality rate at 24 h and higher hematocrit at 6 h, indicating severe disease in these animals. At 6 and 15 h, all groups displayed similar peritoneal resorption. After 24 h, all groups with active inflammation showed significantly higher resorption than laparotomy controls. We conclude that peritoneal resorption as defined is independent of the severity and mode of induction of acute experimental pancreatitis and that it is the same as in bacterial peritonitis.
在大鼠中，研究了分子量为10,000的异硫氰酸荧光素偶联（FITC）葡聚糖在6、15和24小时后从腹膜的吸收情况，这些大鼠分别患有：（1）仅行剖腹术（LC）；（2）细菌性腹膜炎（BP）；（3）胆汁性急性胰腺炎（AP）；（4）污染胆汁诱导的急性胰腺炎（AIP）；（5）急性胰腺炎期间注射雨蛙肽（CAP）。AIP组和CAP组动物在24小时时死亡率显著更高，在6小时时血细胞比容更高，表明这些动物病情严重。在6和15小时时，所有组的腹膜吸收情况相似。24小时后，所有有活动性炎症的组的吸收情况均显著高于剖腹术对照组。我们得出结论，所定义的腹膜吸收与急性实验性胰腺炎的严重程度和诱导方式无关，且与细菌性腹膜炎相同。
