Svensson C, Sjödahl R, Tagesson C, Ihse I
Department of Surgery, University Hospital, Linköping, Sweden.
Int J Pancreatol. 1989 Feb;4(1):91-8. doi: 10.1007/BF02924150.
The peritoneal permeability to differently sized dextran molecules; Mw 4,000, 10,000, 20,000, and 40,000 was investigated in rats with bile-induced acute pancreatitis. Following intraperitoneal deposition, repeated blood samples for measurement of the different dextrans were collected. The results showed increased peritoneal permeability to molecules between 4,000-20,000 daltons in animals with pancreatitis, whereas there was no significant difference for molecules of 40,000 daltons compared to healthy control animals. Also, the passage of phospholipase A2 (Mw 14,000) over the peritoneal membrane was increased during pancreatitis. It is suggested that the transperitoneal route may be of pathophysiological importance in the development of the systemic components of severe acute pancreatitis.
研究了胆汁诱导的急性胰腺炎大鼠腹膜对不同大小葡聚糖分子（分子量4000、10000、20000和40000）的通透性。腹腔内注入后，采集重复血样以测定不同的葡聚糖。结果显示，胰腺炎动物对分子量在4000至20000道尔顿之间的分子的腹膜通透性增加，而与健康对照动物相比，分子量40000道尔顿的分子没有显著差异。此外，胰腺炎期间磷脂酶A2（分子量14000）透过腹膜的量增加。提示经腹膜途径在重症急性胰腺炎全身并发症的发生发展中可能具有病理生理学意义。
