蛙皮素激素刺激对大鼠急性实验性胰腺炎的影响。

Influence of hormonal stimulation by caerulein on acute experimental pancreatitis in the rat.

作者信息

Evander A, Ihse I, Lundquist I

出版信息

Eur Surg Res. 1981;13(4):257-68. doi: 10.1159/000128192.

Abstract

The influence of hormonal stimulation by caerulein administration on acute experimental pancreatitis was investigated in the rat. An experimental model of moderate acute pancreatitis was selected after injecting buffer solution containing sodium taurodeoxycholate and various concentrations of trypsin into the bile-pancreatic duct. During acute experimental pancreatitis caerulein administration increased the mortality rate, the incidence of ascites and the activity of amylase in ascites. Caerulein rendered the pancreatitis more severe also as judged from blind macroscopic evaluation. Amylase and insulin levels in serum and plasma were elevated 6 and 25 h after induction of pancreatitis irrespective of caerulein administration. In pancreatitic rats caerulein decreased the activities of digestive enzymes in pancreatic tissue. The results show that hormonal stimulation by the cholecystokinin-pancreozymin analogue caerulein during acute experimental pancreatitis is harmful.

摘要

在大鼠中研究了注射蛙皮素进行激素刺激对急性实验性胰腺炎的影响。在向胆胰管注射含有牛磺脱氧胆酸钠和各种浓度胰蛋白酶的缓冲溶液后，选择了中度急性胰腺炎的实验模型。在急性实验性胰腺炎期间，注射蛙皮素会增加死亡率、腹水发生率以及腹水中淀粉酶的活性。从盲法宏观评估来看，蛙皮素也会使胰腺炎更加严重。无论是否注射蛙皮素，在胰腺炎诱导后6小时和25小时，血清和血浆中的淀粉酶和胰岛素水平都会升高。在患胰腺炎的大鼠中，蛙皮素会降低胰腺组织中消化酶的活性。结果表明，在急性实验性胰腺炎期间，胆囊收缩素-促胰酶素类似物蛙皮素的激素刺激是有害的。