Habara Y, Uehara A, Takasugi Y, Namiki M, Kanno T
Department of Molecular Physiology, Institute for Physiological Sciences, Okazaki, Japan.
Int J Pancreatol. 1991 Nov-Dec;10(3-4):237-45. doi: 10.1007/BF02924161.
Secretory responses of the exocrine pancreas in the obese Zucker rat with an inherited genetic disorder were compared with those in lean control rats. Amylase concentration in pancreatic acinar cells of obese rats was reduced to 62% of the control value, whereas trypsinogen concentration was increased to 269%. The activity ratio of amylase to trypsinogen in the pancreatic acini of obese rats was about one-fourth of that in controls. The activity ratio of amylase to trypsinogen in pancreatic juice released by stimulation with varying concentrations of CCK8 or carbachol in the obese rats was also reduced to one-fourth of that in control rats. The concentration of the secretagogs inducing half-maximal secretory responses (EC50) in the obese rats was almost identical to that in the controls. The downward shift of the dose-response relation for these secretagogs in the acini of obese rats was analogous to that in streptozotocin-induced diabetic rats, cold-exposed rats, or lactating rats, as demonstrated previously. The present results may be explained by the changes in enzyme content and secretory responses found in pancreatic acini of obese Zucker rats, which would be attributable mainly to congenital disturbance in "insulo-acinar axis."
将患有遗传性基因疾病的肥胖 Zucker 大鼠的外分泌胰腺分泌反应与瘦素对照大鼠的分泌反应进行了比较。肥胖大鼠胰腺腺泡细胞中的淀粉酶浓度降至对照值的 62%，而胰蛋白酶原浓度则升至 269%。肥胖大鼠胰腺腺泡中淀粉酶与胰蛋白酶原的活性比约为对照大鼠的四分之一。在肥胖大鼠中，用不同浓度的 CCK8 或卡巴胆碱刺激释放的胰液中，淀粉酶与胰蛋白酶原的活性比也降至对照大鼠的四分之一。肥胖大鼠中诱导半数最大分泌反应（EC50）的促分泌剂浓度与对照大鼠几乎相同。如先前所示，肥胖大鼠腺泡中这些促分泌剂的剂量反应关系向下移动类似于链脲佐菌素诱导的糖尿病大鼠、冷暴露大鼠或泌乳大鼠中的情况。目前的结果可能由肥胖 Zucker 大鼠胰腺腺泡中发现的酶含量和分泌反应变化来解释，这主要归因于“胰岛-腺泡轴”的先天性紊乱。
