肥胖 Zucker 大鼠胰腺酶含量及分泌的变化
Changes in content and secretion of pancreatic enzymes in the obese Zucker rat.
作者信息
Bruzzone R, Trimble E R, Gjinovci A, Renold A E
出版信息
Biochem J. 1984 Apr 1;219(1):333-6. doi: 10.1042/bj2190333.
Abstract
The contents of three major digestive enzymes (amylase, lipase and chymotrypsinogen) were measured in the obese Zucker rat. Only minimal changes were found in 7-week-old rats, but in adult obese rats (14-16 weeks) the amylase content was decreased by 50%, whereas the lipase and chymotrypsinogen contents were increased by 45% and 20%, respectively, compared with lean controls. Abnormalities of enzyme secretion were also found. Since the changes observed in enzyme proportions in adult obese Zucker rats are qualitatively similar to those observed in insulinopenic diabetes and other states associated with decreased glucose metabolism, it is speculated that the abnormalities found in the obese Zucker rat may be due to decreased glucose metabolism in the exocrine tissue consequent to insulin resistance.
摘要
在肥胖的 Zucker 大鼠中测量了三种主要消化酶（淀粉酶、脂肪酶和胰凝乳蛋白酶原）的含量。在 7 周龄的大鼠中仅发现了微小的变化，但与瘦对照相比，成年肥胖大鼠（14 - 16 周）的淀粉酶含量降低了 50%，而脂肪酶和胰凝乳蛋白酶原的含量分别增加了 45%和 20%。还发现了酶分泌异常。由于在成年肥胖 Zucker 大鼠中观察到的酶比例变化在质量上与在胰岛素缺乏性糖尿病和其他与葡萄糖代谢降低相关的状态中观察到的变化相似，推测在肥胖 Zucker 大鼠中发现的异常可能是由于胰岛素抵抗导致外分泌组织中葡萄糖代谢降低所致。
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本文引用的文献
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