孕早期颈部透明带测量值处于第99百分位数或更高且核型正常的儿童的长期预后：一项前瞻性研究
Long-term outcome of children born after a first-trimester measurement of nuchal translucency at the 99th percentile or greater with normal karyotype: a prospective study.
作者信息
Senat Marie-Victoire, Bussières Laurence, Couderc Sophie, Roume Joelle, Rozenberg Patrick, Bouyer Jean, Ville Yves
机构信息
Department of Obstetrics and Gynecology, CHI Poissy-Saint Germain, Paris-Ile-de-France-Ouest Medical School, Paris, France.
出版信息
Am J Obstet Gynecol. 2007 Jan;196(1):53.e1-6. doi: 10.1016/j.ajog.2006.08.026.
Abstract
OBJECTIVE
This study was undertaken to assess the long-term outcome of children born after a first-trimester measurement of nuchal translucency (NT) at the 99th percentile or greater during routine first-trimester screening in an unselected population.
STUDY DESIGN
One hundred sixty-two infants were born alive. Clinical examination as well as a questionnaire to the parents (Ages and Stages Questionnaires [ASQ]) at the age of 2 years were obtained in 160 children. Our study population was compared with an external control group made of the 370 term control children.
RESULTS
The prevalence of abnormal clinical pediatric examination and ASQ results at 2 years were not associated with NT thickness. Comparison with an external control group did not demonstrate an increased incidence of developmental delay.
CONCLUSION
Parents should be informed that when the fetus is shown to be normal by ultrasound at 22-24 weeks of gestation the risk of adverse neonatal outcome or developmental delay in early childhood is not increased.
摘要
目的
本研究旨在评估在未选择人群的常规孕早期筛查中，孕早期颈部透明带（NT）测量值处于第99百分位数或更高水平的情况下出生的儿童的长期结局。
研究设计
162名婴儿存活出生。对160名儿童进行了临床检查，并在其2岁时向家长发放了问卷（年龄与发育进程问卷[ASQ]）。我们的研究人群与由370名足月儿组成的外部对照组进行了比较。
结果
2岁时临床儿科检查异常和ASQ结果与NT厚度无关。与外部对照组相比，未显示出发育延迟发生率增加。
结论
应告知家长，当妊娠22 - 24周时超声显示胎儿正常时，新生儿不良结局或幼儿期发育延迟的风险不会增加。
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