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Screening for Down syndrome using first-trimester combined screening followed by second-trimester ultrasound examination in an unselected population.在未经过选择的人群中，采用孕早期联合筛查随后进行孕中期超声检查来筛查唐氏综合征。
Am J Obstet Gynecol. 2006 Nov;195(5):1379-87. doi: 10.1016/j.ajog.2006.02.046. Epub 2006 May 24.
2
First-trimester septated cystic hygroma: prevalence, natural history, and pediatric outcome.孕早期分隔性囊状水囊瘤：患病率、自然病史及儿科预后
Obstet Gynecol. 2005 Aug;106(2):288-94. doi: 10.1097/01.AOG.0000173318.54978.1f.
3
Are maternal hypertension and small-for-gestational age risk factors for severe intraventricular hemorrhage and cystic periventricular leukomalacia? Results of the EPIPAGE cohort study.母亲高血压和小于胎龄儿是严重脑室内出血和脑室周围白质软化症的危险因素吗？EPIPAGE队列研究结果
Am J Obstet Gynecol. 2005 Jul;193(1):178-84. doi: 10.1016/j.ajog.2004.11.057.
4
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Am J Obstet Gynecol. 2005 Apr;192(4):1005-21. doi: 10.1016/j.ajog.2004.12.093.
5
[Long-term follow-up of children with increased nuchal translucency and normal karyotype].颈部透明带增厚且核型正常儿童的长期随访
J Gynecol Obstet Biol Reprod (Paris). 2005 Feb;34(1 Suppl):S97-102. doi: 10.1016/s0368-2315(05)82695-x.
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Parent-completed developmental screening in a Norwegian population sample: a comparison with US normative data.挪威人群样本中家长完成的发育筛查：与美国常模数据的比较。
Acta Paediatr. 2004 Nov;93(11):1525-9. doi: 10.1080/08035250410033051.
7
Survival of very preterm infants: Epipage, a population based cohort study.极早产儿的存活情况：基于人群的队列研究Epipage
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Pregnancy outcomes with increased nuchal translucency after routine Down syndrome screening.
Int J Gynaecol Obstet. 2004 Jan;84(1):5-9. doi: 10.1016/s0020-7292(03)00206-6.
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Pregnancy outcome in fetuses with increased nuchal translucency and normal karyotype.颈部透明带增厚且核型正常胎儿的妊娠结局
Prenat Diagn. 2002 May;22(5):345-9. doi: 10.1002/pd.321.
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Fetal nuchal translucency and normal chromosomes: a long-term follow-up study.
Ultrasound Obstet Gynecol. 2001 Jul;18(1):18-22. doi: 10.1046/j.1469-0705.2001.00481.x.

孕早期颈部透明带测量值处于第99百分位数或更高且核型正常的儿童的长期预后：一项前瞻性研究

Long-term outcome of children born after a first-trimester measurement of nuchal translucency at the 99th percentile or greater with normal karyotype: a prospective study.

作者信息

Senat Marie-Victoire, Bussières Laurence, Couderc Sophie, Roume Joelle, Rozenberg Patrick, Bouyer Jean, Ville Yves

机构信息

Department of Obstetrics and Gynecology, CHI Poissy-Saint Germain, Paris-Ile-de-France-Ouest Medical School, Paris, France.

出版信息

Am J Obstet Gynecol. 2007 Jan;196(1):53.e1-6. doi: 10.1016/j.ajog.2006.08.026.

DOI:10.1016/j.ajog.2006.08.026
PMID:17240232
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1933588/
Abstract

OBJECTIVE

This study was undertaken to assess the long-term outcome of children born after a first-trimester measurement of nuchal translucency (NT) at the 99th percentile or greater during routine first-trimester screening in an unselected population.

STUDY DESIGN

One hundred sixty-two infants were born alive. Clinical examination as well as a questionnaire to the parents (Ages and Stages Questionnaires [ASQ]) at the age of 2 years were obtained in 160 children. Our study population was compared with an external control group made of the 370 term control children.

RESULTS

The prevalence of abnormal clinical pediatric examination and ASQ results at 2 years were not associated with NT thickness. Comparison with an external control group did not demonstrate an increased incidence of developmental delay.

CONCLUSION

Parents should be informed that when the fetus is shown to be normal by ultrasound at 22-24 weeks of gestation the risk of adverse neonatal outcome or developmental delay in early childhood is not increased.

摘要

目的

本研究旨在评估在未选择人群的常规孕早期筛查中，孕早期颈部透明带（NT）测量值处于第99百分位数或更高水平的情况下出生的儿童的长期结局。

研究设计

162名婴儿存活出生。对160名儿童进行了临床检查，并在其2岁时向家长发放了问卷（年龄与发育进程问卷[ASQ]）。我们的研究人群与由370名足月儿组成的外部对照组进行了比较。

结果

2岁时临床儿科检查异常和ASQ结果与NT厚度无关。与外部对照组相比，未显示出发育延迟发生率增加。

结论

应告知家长，当妊娠22 - 24周时超声显示胎儿正常时，新生儿不良结局或幼儿期发育延迟的风险不会增加。