Shi Yun, Wu Chao, Zhou Wei-Ying, Mao Xu-Hu, Guo Gang, Zou Quan-Ming
Department of Clinical Microbiology and Immunology, College of Medical Laboratory Science, The Third Military Medical University, Chongqing 400038, People's Republic of China.
Vaccine. 2007 Mar 30;25(14):2583-90. doi: 10.1016/j.vaccine.2006.12.024. Epub 2006 Dec 27.
CD4+ T cells play important roles in protection against Helicobacter pylori (H. pylori) infection. In order to better understand the immune responses of H. pylori infection and improve immune interventions against this pathogen, we identified the Th epitopes in UreB of H. pylori, an excellent vaccine candidate antigen. By using the RANKPEP prediction algorithm, we have identified and characterized three Th epitopes within the UreB antigen, which can be recognized by CD4+ T cells from BALB/c (H-2d) mice. They were U(546-561), U(229-244), and U(237-251). These epitopes have important value for studying the immune response of H. pylori infection and for designing effective vaccine against H. pylori.
CD4+ T细胞在抵御幽门螺杆菌（H. pylori）感染中发挥着重要作用。为了更好地理解幽门螺杆菌感染的免疫反应并改善针对这种病原体的免疫干预措施，我们鉴定了幽门螺杆菌UreB中的Th表位，UreB是一种优秀的候选疫苗抗原。通过使用RANKPEP预测算法，我们在UreB抗原中鉴定并表征了三个Th表位，它们可被来自BALB/c（H-2d）小鼠的CD4+ T细胞识别。它们分别是U(546 - 561)、U(229 - 244)和U(237 - 251)。这些表位对于研究幽门螺杆菌感染的免疫反应以及设计针对幽门螺杆菌的有效疫苗具有重要价值。
