Azekawa T, Sano A, Sei H, Morita Y
Department of Physiology, School of Medicine, University of Tokushima, Japan.
Neurosci Lett. 1991 Oct 28;132(1):93-6. doi: 10.1016/0304-3940(91)90441-u.
We observed 24 h changes of 'extracellular' indoleamines in pineal microdialysates taken from freely moving rats under a 12 h light/12 h dark cycle. Pineal indoleamines in microdialysates were analyzed by high-performance liquid chromatography with electrochemical detection. Consequently, they exhibited marked diurnal variations. The diurnal level in the extracellular 5-HT, higher for the light and lower for the dark, was parallel to that in 5-hydroxyindoleacetic acid and diametrically opposite to that in N-acetylserotonin (NAS). The release of 5-HT into the extracellular space transiently increased for the first 2 h after the dark onset and then became lower during the dark.
我们观察了在12小时光照/12小时黑暗周期下自由活动大鼠的松果体微透析液中“细胞外”吲哚胺的24小时变化。通过高效液相色谱-电化学检测法分析微透析液中的松果体吲哚胺。结果显示，它们呈现出明显的昼夜变化。细胞外5-羟色胺（5-HT）的昼夜水平在光照时较高，黑暗时较低，与5-羟吲哚乙酸的水平平行，与N-乙酰血清素（NAS）的水平完全相反。黑暗开始后的前2小时，5-HT向细胞外空间的释放短暂增加，然后在黑暗期间降低。
