卡比多巴对大鼠松果体和下丘脑吲哚胺浓度的差异作用。
Differential effect of carbidopa on the concentration of rat pineal and hypothalamic indoleamines.
作者信息
Oxenkrug G F, McIntyre I M, Novak E A, Hryhorczuk L M, Frohman C E
出版信息
J Pineal Res. 1984;1(4):349-53. doi: 10.1111/j.1600-079x.1984.tb00225.x.
Carbidopa, an aromatic acid decarboxylase inhibitor, has been shown to significantly decrease the pineal concentration of melatonin, N-acetyl serotonin (NAS), serotonin (5-HT), and 5-hydroxyindoleacetic acid (5-HIAA) but not the hypothalamic concentrations of these indoles. Increased levels of 5-hydroxytryptophan (5-HTP) indicate that carbidopa directly inhibits 5-HTP decarboxylation, thus limiting 5-HT production. Possible practical implications of selective inhibition of pineal indoleamines by carbidopa are discussed.
卡比多巴是一种芳香酸脱羧酶抑制剂，已被证明可显著降低褪黑素、N - 乙酰血清素（NAS）、血清素（5 - HT）和5 - 羟吲哚乙酸（5 - HIAA）在松果体中的浓度，但不会降低这些吲哚在 hypothalamic 中的浓度。5 - 羟色氨酸（5 - HTP）水平升高表明卡比多巴直接抑制5 - HTP脱羧，从而限制5 - HT的产生。文中讨论了卡比多巴对松果体吲哚胺的选择性抑制可能具有的实际意义。 （注：原文中hypothalamic可能是“下丘脑的”意思，但由于没有更多背景信息，这里直接保留英文）
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