Knyihár-Csillik E, Kreutzberg G W, Raivich G, Csillik B
Department of Anatomy, Albert Szent-Györgyi Medical University, Szeged, Hungary.
Acta Histochem. 1991;91(1):77-83. doi: 10.1016/S0065-1281(11)80299-0.
Blockade of retrograde axoplasmic transport in peripheral nerves, by means of perineurally applied microtubule inhibitors, results in an increased vasoactive intestinal polypeptide (VIP) reaction of the segmentally related, ipsilateral upper dorsal horn. Similar effect is elicited by the perineural application of an anti-Nerve Growth Factor (anti-NGF) serum. At the same time, both treatments result in depletion of Substance P from the same region of the spinal cord. It is assumed that this striking example of transmitter plasticity, obviously taking place at the molecular level, is due to a stimulating effect of NGF upon the perikaryal Substance P-synthesizing mechanism in dorsal root ganglion cells, and the inhibitory effect of NGF upon the VIP synthesizing machinery in these same nerve cells.
通过在神经周围应用微管抑制剂来阻断外周神经中的逆行轴浆运输，会导致节段相关的同侧上背角的血管活性肠肽（VIP）反应增强。在神经周围应用抗神经生长因子（anti-NGF）血清也会产生类似的效果。同时，这两种处理都会导致脊髓同一区域的P物质耗竭。据推测，这种明显在分子水平发生的递质可塑性的显著例子，是由于NGF对背根神经节细胞中核周P物质合成机制的刺激作用，以及NGF对这些相同神经细胞中VIP合成机制的抑制作用。
