2006年，瘢痕疙瘩的治疗仍然是一项挑战吗？
Is the treatment of keloid scars still a challenge in 2006?
作者信息
De Lorenzi Francesca, Tielemans Hanneke J P, van der Hulst René R W J, Rhemrev Rose, Nieman Fred H M, Lutgens Ludy C H W, Boeckx Willy D
机构信息
Department of Plastic and Reconstructive Surgery, University Hospital of Maastricht, Maastricht, The Netherlands.
出版信息
Ann Plast Surg. 2007 Feb;58(2):186-92. doi: 10.1097/01.sap.0000237761.52586.f9.
BACKGROUND
Several options are described to treat keloid scars, none of them being 100% successful. Radiotherapy is suggested to have the most significant effect on recurrence rate.
OBJECTIVES
The aim of the study is to confirm the effectiveness of iridium brachytherapy combined with surgery and to evaluate patient satisfaction.
PATIENTS AND METHODS
We retrospectively enrolled 24 patients with 30 keloids, treated by surgical excision and iridium 192 high-dose-rate (HDR) brachytherapy.
RESULTS
We observed a significant difference in scar thickness before and after the treatment (P < 0.001). With regard to patient satisfaction and complaints, 79.1% of them had no pain and irritation after treatment, 79.2% of patients would recommend this treatment to other patients, and 87.5% would undergo this treatment again if necessary.
CONCLUSIONS
Our results confirm the effectiveness of surgical keloid excision followed by HDR brachytherapy in primary treatment or if other alternative methods have failed.
背景
治疗瘢痕疙瘩有多种方法，但均未达到100%的成功率。放疗对复发率的影响最为显著。
目的
本研究旨在证实铱近距离放疗联合手术的有效性，并评估患者满意度。
患者与方法
我们回顾性纳入了24例患有30个瘢痕疙瘩的患者，这些患者均接受了手术切除及铱192高剂量率（HDR）近距离放疗。
结果
我们观察到治疗前后瘢痕厚度存在显著差异（P < 0.001）。在患者满意度和投诉方面，79.1%的患者治疗后无疼痛和刺激感，79.2%的患者会向其他患者推荐这种治疗方法，87.5%的患者如有必要会再次接受这种治疗。
结论
我们的结果证实了瘢痕疙瘩手术切除后行HDR近距离放疗在初始治疗或其他替代方法失败时的有效性。
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