使用高剂量率铱192模具进行术后放疗预防耳垂瘢痕疙瘩
Postoperative radiotherapy with high dose rate iridium 192 mould for prevention of earlobe keloids.
作者信息
Narkwong Ladawan, Thirakhupt Poth
机构信息
Radiation Oncology Division, Department of Radiology, Faculty of Medicine, Ramathibodi Hospital, Mahidol University.
出版信息
J Med Assoc Thai. 2006 Apr;89(4):428-33.
BACKGROUND
A 50% to 80% recurrence rate of earlobe keloids can occur following a simple excision. Many modalities, including radiotherapy, have been suggested to reduce the postoperation recurrence.
OBJECTIVE
The aim of the present study was to determine the efficacy of postoperative radiotherapy by a high dose rate Iridium 192 mould in the prevention of earlobe keloids recurrence.
MATERIAL AND METHOD
Between March 1999 and March 2003, 22 patients with 24 earlobe keloids were treated by radiotherapy immediately following surgical excision. A dose of 15 Gray in 3 fractions was delivered at a point placed 5 mm from the axis of the Iridium sources.
RESULTS
From the 22 patients with 24 keloids who were treated, 15 patients with 16 keloids were followed for a minimum of 6 months. Recurrence occurred in two keloids (12.5%). There were no severe adverse effects.
CONCLUSION
Postoperative radiotherapy by high dose rate Iridium 192 mould was an effective prevention of earlobe keloids recurrence. It was well tolerated and did not present any significant side effects.
背景
耳垂瘢痕疙瘩单纯切除术后复发率可达50%至80%。人们提出了许多方法，包括放射治疗，以降低术后复发率。
目的
本研究旨在确定高剂量率铱192模具术后放疗预防耳垂瘢痕疙瘩复发的疗效。
材料与方法
1999年3月至2003年3月期间，22例患有24个耳垂瘢痕疙瘩的患者在手术切除后立即接受放射治疗。在距离铱源轴5毫米处的一点给予15格雷分3次的剂量。
结果
在接受治疗的22例患有24个瘢痕疙瘩的患者中，15例患有16个瘢痕疙瘩的患者被随访至少6个月。两个瘢痕疙瘩（12.5%）出现复发。未出现严重不良反应。
结论
高剂量率铱192模具术后放疗是预防耳垂瘢痕疙瘩复发的有效方法。耐受性良好，未出现任何明显副作用。
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