在非黑色素瘤皮肤癌诊断中，分光光度法皮内分析与临床判断的前瞻性比较。
A prospective comparison of spectrophotometric intracutaneous analysis to clinical judgment in the diagnosis of nonmelanoma skin cancer.
作者信息
Tehrani Hamid, Walls Joe, Price Gill, Cotton Symon, Sassoon Elaine M, Hall Per N
机构信息
Department of Plastic Surgery, Norfolk and Norwich University Hospital, Norwich, England.
出版信息
Ann Plast Surg. 2007 Feb;58(2):209-11. doi: 10.1097/01.sap.0000235476.10517.bb.
INTRODUCTION
Research indicates that spectrophotometric intracutaneous analysis (SIAscopy) may be a useful adjunct in nonmelanoma skin cancer (NMSC) diagnosis. A study was performed to prospectively assess the accuracy of NMSC diagnosis by the SIAscope as compared with a clinician.
METHODS
Prior to excision, 323 consecutive lesions were examined and diagnosed by a clinician. SIAgraphs were then taken of the lesions and examined blindly at a later date. Diagnostic accuracy for the clinician and SIAscope was compared between the clinician and SIAscope and to histology.
RESULTS
Sensitivity, specificity, positive and negative predictive values for clinical diagnoses were 95.6%, 75.8%, 0.79, and 0.95, respectively. Results for SIA diagnoses were 97.5%, 86.7%, 0.88, and 0.97. Statistical comparison revealed comparable sensitivities for the 2 groups but significantly better specificity for the SIAscope at the 95% confidence level.
CONCLUSION
This study indicates that the SIAscope may be useful in NMSC diagnosis, with accuracies comparable to a clinician.
引言
研究表明，分光光度法皮内分析（SIAscopy）可能是一种辅助诊断非黑素瘤皮肤癌（NMSC）的有用方法。本研究旨在前瞻性地评估SIAscope诊断NMSC的准确性，并与临床医生的诊断结果进行比较。
方法
在切除之前，由一名临床医生对323个连续的病变进行检查和诊断。随后拍摄病变的SIA图像，并在之后进行盲法检查。将临床医生和SIAscope的诊断准确性与组织学结果进行比较。
结果
临床诊断的敏感性、特异性、阳性预测值和阴性预测值分别为95.6%、75.8%、0.79和0.95。SIA诊断的结果分别为97.5%、86.7%、0.88和0.97。统计学比较显示，两组的敏感性相当，但在95%置信水平下，SIAscope的特异性显著更高。
结论
本研究表明，SIAscope在NMSC诊断中可能有用，其准确性与临床医生相当。
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