Haniffa M A, Lloyd J J, Lawrence C M
Department of Dermatology and Regional Medical Physics Department, Royal Victoria Infirmary, Newcastle-upon-Tyne, UK.
Br J Dermatol. 2007 Jun;156(6):1350-2. doi: 10.1111/j.1365-2133.2007.07932.x.
Skin imaging devices to aid melanoma diagnosis have been developed in recent years but few have been assessed clinically.
To investigate if a spectrophotometric skin imaging device, the SIAscope, could increase a dermatologist's ability to distinguish melanoma from nonmelanoma in a melanoma screening clinic.
Eight hundred and eighty-one pigmented lesions from 860 patients were prospectively assessed clinically and with the aid of the spectrophotometric device by a dermatologist. Assessment before and after spectrophotometric imaging was made and compared with histology, where available, or with the clinical diagnosis of a dermatologist with 20 years of experience.
One hundred and seventy-nine biopsies were performed, with 31 melanomas diagnosed. Sensitivity and specificity for melanoma diagnosis before and after spectrophotometry were 94% and 91% vs. 87% and 91%, respectively, with no significant difference in the area under the receiver operating characteristic curves (0.932 and 0.929).
Our study provides no evidence for the use of SIAscope by dermatologists to help distinguish melanoma from benign lesions.
近年来已开发出辅助黑色素瘤诊断的皮肤成像设备，但很少有进行临床评估的。
研究一种分光光度皮肤成像设备SIAscope能否提高皮肤科医生在黑色素瘤筛查诊所中将黑色素瘤与非黑色素瘤区分开来的能力。
由一名皮肤科医生对860例患者的881个色素沉着病变进行前瞻性临床评估，并借助分光光度设备进行评估。在分光光度成像前后进行评估，并与可获得的组织学结果或与一名有20年经验的皮肤科医生的临床诊断进行比较。
共进行了179次活检，诊断出31例黑色素瘤。分光光度法前后对黑色素瘤诊断的敏感性和特异性分别为94%和91%，而87%和91%，受试者工作特征曲线下面积无显著差异（0.932和0.929）。
我们的研究没有提供证据支持皮肤科医生使用SIAscope来帮助区分黑色素瘤与良性病变。
