Saltzstein Sidney L, Behling Cynthia A
Department of Pathology, School of Medicine, University of California San Diego, San Diego, USA.
J Clin Gastroenterol. 2007 Feb;41(2):173-7. doi: 10.1097/01.mcg.0000225550.26751.6a.
Using a data set of more than 200,000 cases, we can measure the effects of age, time, sex, and race/ethnicity on the shift of the site of origin of colorectal adenocarcinoma from the left to the right side.
As people become older, there is a shift of the site of origin of adenocarcinoma of the colorectum from the left to the right side. Although some studies do show some relationship of this shift, in addition to age, to race/ethnicity and to sex, there are no large, total population-based data studying the effects of these factors and time trends in this shift.
213,383 cases of adenocarcinoma of the colorectum for the years 1988 to 2003 from the California Cancer Registry have been studied.
The left-to-right shift increases significantly with increasing age and year of diagnosis, and is greater in women than in men and is greater in whites than in other racial/ethnic groups. The time-related shift is a reflection of a lesser decrease in the incidence of colorectal adenocarcinoma on the right side than on the left.
The most attractive hypothesis is that a greater likelihood of prior polypectomy, and thus prevention of more cancers, occurs on the left side than on the right.
利用一个超过20万例病例的数据集，我们能够衡量年龄、时间、性别以及种族/族裔对结直肠腺癌起源部位从左侧向右侧转移的影响。
随着人们年龄增长，结直肠癌的起源部位会从左侧向右侧转移。尽管一些研究确实表明这种转移，除了与年龄有关外，还与种族/族裔和性别有关，但尚无基于全人群的大型数据来研究这些因素的影响以及这种转移的时间趋势。
对加利福尼亚癌症登记处1988年至2003年期间的213383例结直肠腺癌病例进行了研究。
从左侧向右侧的转移随着年龄增长和诊断年份的增加而显著增加，女性比男性更明显，白人比其他种族/族裔群体更明显。与时间相关的转移反映出右侧结直肠腺癌发病率的下降幅度小于左侧。
最有吸引力的假设是，左侧比右侧更有可能进行过息肉切除术，从而预防了更多癌症。
