Jansen T L, Tan A C, Wollersheim H, Benraad T J, Thien T
Department of Medicine, St. Radboud Hospital, University of Nijmegen, The Netherlands.
J Cardiovasc Pharmacol. 1991 Oct;18(4):622-30. doi: 10.1097/00005344-199110000-00020.
The microcirculatory responses to systemically administered alpha-human atrial natriuretic factor [99-126)hANF) (ANF) were investigated in the skin of eight young (18-25 years) and eight elderly (71-84 years) healthy volunteers in a double-blind, randomized, placebo-controlled study. Laser-Doppler flux (LDF), transcutaneous oxygen pressure (TcPO2), and skin temperatures on the finger (Td) and on the cheek (Tc) were measured during 60 min of i.v. ANF administration at a low rate (0.25 micrograms/min), resulting in plasma ANF concentrations in the upper normal range, and at a high rate (2.0 micrograms/min), inducing a 17- to 23-fold increase in plasma ANF. ANF infusion did not induce consistent changes in TcPO2 or Td at either rate. Placebo-corrected LDF increased significantly following low-rate ANF infusion in the elderly but remained unchanged in the young (mean +/- SD) +22 +/- 21% (p less than 0.05) and +7 +/- 32% (p greater than 0.1), respectively; following high-rate ANF infusion in LDF the changes were greater, with +28 +/- 56% and +19 +/- 42%, respectively. Because of the large SD the increases were no longer significant. During high-rate ANF infusion Tc remained unchanged in the young, but in the elderly Tc decreased--1.1 +/- 1.3% (p less than 0.05), which is probably due to the fall in blood pressure, which was more pronounced in the elderly than in the young: mean arterial blood pressure (MAP) decreased -9 +/- 3% (p less than 0.05) in the elderly and just -6 +/- 3% (p less than 0.05) in the young, both corrected for placebo changes.(ABSTRACT TRUNCATED AT 250 WORDS)
在一项双盲、随机、安慰剂对照研究中，对8名年轻（18 - 25岁）和8名老年（71 - 84岁）健康志愿者的皮肤进行研究，观察其对静脉注射α - 人心房利钠因子[99 - 126]hANF）（ANF）的微循环反应。在静脉注射ANF的60分钟内，以低速率（0.25微克/分钟）给药，使血浆ANF浓度处于正常上限范围，以及高速率（2.0微克/分钟）给药，使血浆ANF升高17至23倍，期间测量激光多普勒血流（LDF）、经皮氧分压（TcPO2）以及手指（Td）和脸颊（Tc）的皮肤温度。无论哪种速率，ANF输注均未引起TcPO2或Td的一致变化。低速率ANF输注后，老年组安慰剂校正后的LDF显著增加，而年轻组无变化，分别为（均值±标准差）+22±21%（p＜0.05）和+7±32%（p＞0.1）；高速率ANF输注后，LDF的变化更大，分别为+28±56%和+19±42%。由于标准差较大，这些增加不再显著。高速率ANF输注期间，年轻组的Tc无变化，但老年组的Tc下降了-1.1±1.3%（p＜0.05），这可能是由于血压下降，且老年组比年轻组更明显：老年组平均动脉血压（MAP）下降了-9±3%（p＜0.05），年轻组仅下降了-6±3%（p＜0.05），两者均校正了安慰剂变化。（摘要截短于250字）
