Rölleke T, Berke B, Arndt J O
Institut für Experimentelle Anaesthesiologie, Heinrich-Heine-Universität Düsseldorf, FRG.
Basic Res Cardiol. 1994 Mar-Apr;89(2):192-205. doi: 10.1007/BF00788737.
We studied the effects of hANP 99-126 on capillary filtration and venous compliance in both the calf (mainly skeletal muscle) and foot (mainly skin) of humans. Six healthy mean received ANP (intravenous injection of 25 micrograms followed by continuous infusion of 0.1 microgram.kg-1.min-1) for 30 min. Another six men served as time controls. Capillary filtration coefficient, venous compliance, and also volume and blood flow of both calf and foot were measured repeatedly by occlusion plethysmography before, during, and after ANP. Additionally, we determined hematocrit, central venous pressure, venous pressure in the foot, arterial pressure, and heart rate. Filtration coefficients, venous compliance, blood flow of both calf and foot as well as arterial blood pressure did not change systematically during the infusion of ANP, and yet leg volume and central venous pressure (3.1 +/- 0.8 cm H2O) decreased while both hematocrit (3.1 +/- 1.0%) and heart rate (17 +/- 11 min-1) increased. Thus, the ANP-evoked decrease in central venous pressure and increase in hematocrit are unrelated to blood pooling or increases in capillary filtration in skeletal muscle and skin of healthy humans.
我们研究了人心房钠尿肽99 - 126对小腿（主要是骨骼肌）和足部（主要是皮肤）毛细血管滤过和静脉顺应性的影响。六名健康男性接受心房钠尿肽（静脉注射25微克，随后以0.1微克·千克⁻¹·分钟⁻¹持续输注）30分钟。另外六名男性作为时间对照。在心房钠尿肽给药前、给药期间和给药后，通过阻断体积描记法反复测量毛细血管滤过系数、静脉顺应性以及小腿和足部的容积与血流量。此外，我们还测定了血细胞比容、中心静脉压、足部静脉压、动脉压和心率。在输注心房钠尿肽期间，滤过系数、静脉顺应性、小腿和足部的血流量以及动脉血压均未出现系统性变化，然而腿部容积和中心静脉压（3.1±0.8厘米水柱）下降，而血细胞比容（3.1±1.0%）和心率（17±11次/分钟）均升高。因此，心房钠尿肽引起的中心静脉压降低和血细胞比容升高与健康人骨骼肌和皮肤中的血液淤积或毛细血管滤过增加无关。
