谷氨酸草酰乙酸转氨酶（GOT）在小鼠中的遗传学：GOT-1 的多态性。

Glutamate oxaloacetate transaminase (got) genetics in the mouse: polymorphism of got-1.

机构信息

Department of Biology, Kline Biology Tower, Yale University, New Haven, Connecticut 06520.

出版信息

Genetics. 1972 Feb;70(2):299-305. doi: 10.1093/genetics/70.2.299.

DOI:10.1093/genetics/70.2.299

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1212735/

Abstract

We have examined a polymorphism for the soluble glutamate oxaloacetate (GOT-1) isozyme system which was found in the Asian mouse Mus castaneus. Variants of GOT-1 segregate as though they are controlled by codominant alleles for a single autosomal locus which we have designated Got-1. No close linkage of genes for soluble and mitochondrial forms of the enzyme, GOT-1 and GOT-2 respectively, was observed. Furthermore, no close linkage of Got-1 and the loci c, Gpi-1, Mod-2, Mod-1, Ld-1, Gpd-1, Pgm-1 or Gpo-1 was observed. Our results demonstrate the utility of sampling Mus from diverse populations to extend the repertoire of polymorphic loci and the genetic linkage map.

摘要

我们研究了亚洲鼠 Mus castaneus 中谷氨酸草酰乙酸（GOT-1）同工酶系统的多态性。GOT-1 的变体似乎是由单个常染色体座位上的共显性等位基因控制的，我们将其命名为 Got-1。未观察到酶的可溶性和线粒体形式 GOT-1 和 GOT-2 的基因之间的紧密连锁。此外，也没有观察到 Got-1 与 c、Gpi-1、Mod-2、Mod-1、Ld-1、Gpd-1、Pgm-1 或 Gpo-1 基因座的紧密连锁。我们的结果表明，从不同种群中采样 Mus 可以扩展多态性基因座和遗传连锁图谱的范围。

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