Lung Cancer Center, West China Hospital, Sichuan University, Chengdu, 610041, China.
Department of Radiation Oncology and Shandong Provincial Key Laboratory of Radiation Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, Shandong, China.
J Exp Clin Cancer Res. 2024 Mar 8;43(1):74. doi: 10.1186/s13046-024-02994-0.
Glutamine metabolism plays a pivotal role in cancer progression, immune cell function, and the modulation of the tumor microenvironment. Dysregulated glutamine metabolism has been implicated in cancer development and immune responses, supported by mounting evidence. Cancer cells heavily rely on glutamine as a critical nutrient for survival and proliferation, while immune cells require glutamine for activation and proliferation during immune reactions. This metabolic competition creates a dynamic tug-of-war between cancer and immune cells. Targeting glutamine transporters and downstream enzymes involved in glutamine metabolism holds significant promise in enhancing anti-tumor immunity. A comprehensive understanding of the intricate molecular mechanisms underlying this interplay is crucial for developing innovative therapeutic approaches that improve anti-tumor immunity and patient outcomes. In this review, we provide a comprehensive overview of recent advances in unraveling the tug-of-war of glutamine metabolism between cancer and immune cells and explore potential applications of basic science discoveries in the clinical setting. Further investigations into the regulation of glutamine metabolism in cancer and immune cells are expected to yield valuable insights, paving the way for future therapeutic interventions.
谷氨酰胺代谢在癌症进展、免疫细胞功能和肿瘤微环境的调节中起着关键作用。越来越多的证据表明，代谢紊乱的谷氨酰胺与癌症的发生和免疫反应有关。癌细胞严重依赖谷氨酰胺作为生存和增殖的关键营养物质，而免疫细胞在免疫反应中需要谷氨酰胺来激活和增殖。这种代谢竞争在癌症和免疫细胞之间创造了一种动态的拉锯战。靶向谷氨酰胺转运体和下游参与谷氨酰胺代谢的酶具有很大的潜力，可以增强抗肿瘤免疫。全面了解这种相互作用背后复杂的分子机制对于开发创新的治疗方法、提高抗肿瘤免疫和改善患者预后至关重要。在这篇综述中，我们全面概述了最近在揭示癌症和免疫细胞之间谷氨酰胺代谢拉锯战方面的进展，并探讨了基础科学发现在临床环境中的潜在应用。进一步研究癌症和免疫细胞中谷氨酰胺代谢的调节有望产生有价值的见解，为未来的治疗干预铺平道路。
