一种新型果蝇，可抑制感染 sigma 病毒的成虫出现症状。
A new strain of Drosophila that inhibits the development of symptoms in imagoes infected with sigma virus.
机构信息
Biology Department, Augsburg College, Minneapolis, Minnesota 55454.
出版信息
Genetics. 1978 Mar;88(3):505-13. doi: 10.1093/genetics/88.3.505.
A strain of Drosophila melanogaster bearing the mutant gene ebony has been found to slow the development of symptoms (carbon dioxide sensitivity) in adult flies inoculated with sigma virus, a member of the rhabdovirus group. This inhibition is made evident by comparing mean incubation times of the virus in ebony and wild-type (Oregon) flies. The increase in mean incubation time in ebony flies has ranged from about 3 to 8 days, depending on the virus strain, amount of virus injected, and the age of the flies at the time of inoculation. This delay in development of symptoms appears to be due to a dominant autosomal gene, although further work is needed to confirm this. When accumulation of infectious virus after inoculation is compared in ebony and Oregon flies, there seems to be no inhibition of multiplication in ebony at the level of the entire fly. The relationship of this work to current theories on the mechanism of symptom production by sigma virus is discussed.
已经发现，携带突变基因 ebony 的黑腹果蝇品系在接种 sigma 病毒（一种弹状病毒科病毒）后，成虫的症状（二氧化碳敏感性）发展速度减缓。通过比较 ebony 和野生型（俄勒冈）果蝇中病毒的平均潜伏期，可以明显看出这种抑制作用。ebony 果蝇的平均潜伏期增加了约 3 到 8 天，具体取决于病毒株、注射的病毒量以及接种时果蝇的年龄。这种症状发展的延迟似乎是由于一个显性常染色体基因引起的，尽管还需要进一步的工作来证实这一点。当比较接种后 ebony 和俄勒冈果蝇中传染性病毒的积累时，在整个果蝇水平上，ebony 似乎并没有抑制病毒的增殖。本文还讨论了这项工作与目前关于 sigma 病毒引起症状产生机制的理论之间的关系。
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