从少数个体估计平均杂合度和遗传距离。
Estimation of average heterozygosity and genetic distance from a small number of individuals.
机构信息
Center for Demographic and Population Genetics, University of Texas at Houston, Texas 77025.
出版信息
Genetics. 1978 Jul;89(3):583-90. doi: 10.1093/genetics/89.3.583.
Abstract
The magnitudes of the systematic biases involved in sample heterozygosity and sample genetic distances are evaluated, and formulae for obtaining unbiased estimates of average heterozygosity and genetic distance are developed. It is also shown that the number of individuals to be used for estimating average heterozygosity can be very small if a large number of loci are studied and the average heterozygosity is low. The number of individuals to be used for estimating genetic distance can also be very small if the genetic distance is large and the average heterozygosity of the two species compared is low.
摘要
评估了样本杂合度和样本遗传距离中涉及的系统偏差的大小，并开发了获得平均杂合度和遗传距离无偏估计的公式。还表明，如果研究大量基因座且平均杂合度较低，则用于估计平均杂合度的个体数量可以非常少。如果比较的两个物种的遗传距离较大且平均杂合度较低，则用于估计遗传距离的个体数量也可以非常少。
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