Genetics. 1980 Nov;96(3):697-710. doi: 10.1093/genetics/96.3.697.
Linkage relationships of 19 enzyme loci have been examined. The chromosomal locations of eight of these loci are formally reported for the first time in this paper. These localizations should assist in the construction of additional useful chromosome marker stocks, especially since several of these enzyme loci lie in regions that were previously poorly mapped. Six loci are on the long arm of chromosome 1. The arrangement is (centromere)-Mdh4-mmm-Pgm1-Adh1-Phi-Gdh1, with about 46% recombination between Mdh4 and Gdh1.-Linkage studies with a2 and pr have resulted in the localization of four enzyme genes to chromosome 5 with arrangement Pgm2-Mdh5-Got3-a2-(centromere)-pr-Got2. Pgm2 lies approximately 35 map units distal to a2 in a previously unmapped region of the short arm of 5, beyond ameiotic.-Approximately 23% recombination was observed between Mdh4 and Pgm1 on chromosome 1, while 17% recombination occurred between Mdh5 and Pgm2 on chromosome 5. Similarly, linkages between Idh1 and Mdh1, about 22 map units apart on chromosome 8, and between Mdh2 and Idh2, less than 5 map units apart on chromosome 6, were observed. Thus, segments of chromosomes 1 and 5 and segments of 6 and 8 may represent duplications on nonhomologous chromosomes.
已经检测了 19 个酶基因座的连锁关系。本文首次正式报告了其中 8 个基因座的染色体位置。这些定位应该有助于构建更多有用的染色体标记品系，特别是因为这些酶基因座中的几个位于以前图谱绘制较差的区域。6 个基因座位于 1 号染色体的长臂上。排列顺序为（着丝粒）-Mdh4-mmm-Pgm1-Adh1-Phi-Gdh1，Mdh4 和 Gdh1 之间的重组率约为 46%。与 a2 和 pr 的连锁研究导致将四个酶基因定位到 5 号染色体上，排列顺序为 Pgm2-Mdh5-Got3-a2-（着丝粒）-pr-Got2。Pgm2 位于 5 号染色体短臂中一个以前未绘制的区域，距离 a2 约 35 个图谱单位，在减数分裂之外。在 1 号染色体上，Mdh4 和 Pgm1 之间观察到约 23%的重组，而在 5 号染色体上，Mdh5 和 Pgm2 之间观察到 17%的重组。同样，在 8 号染色体上大约 22 个图谱单位分离的 Idh1 和 Mdh1 之间，以及在 6 号染色体上不到 5 个图谱单位分离的 Mdh2 和 Idh2 之间也观察到了连锁。因此，染色体 1 和 5 的片段以及染色体 6 和 8 的片段可能代表非同源染色体上的重复。
