口服葡萄糖对人单核血细胞甲状腺激素作用的影响。

Effect of oral glucose feeding on thyroid hormone action in human mononuclear blood cells.

作者信息

Kvetny J, Matzen E L, Hansen J M

机构信息

Department of clinical chemistry and gastroenterology S, Odense University Hospital, Denmark.

出版信息

Thyroidology. 1990 Aug;2(2):53-7.

PMID:1724910

Abstract

The effect of glucose feeding on serum concentrations of thyroid hormones, nuclear T3 binding and thyroid hormone stimulated oxygen consumption and glucose uptake was evaluated. Six persons without thyroid diseases were fed exclusively glucose (2500 kcal/day) for two days. Glucose feeding resulted in the following serum hormone levels (before vs after glucose feeding) T3: 1.07 vs 1.16 nmol/l (p less than 0.05); FT4I: 76 vs 102 a.u. (p less than 0.05) and TSH: 1.48 vs 1.14 mU/l (n.s.). Nuclear T3 binding decreased after glucose feeding; before: maximal binding capacity (MBC) 1.3 +/- 0.5 fmol/100 ug DNA, MBC after glucose feeding: 0.8 +/- 0.2 fmol/100 ug DNA (p less than 0.05). The Ka's were identical in both groups before glucose, Ka: 4.2 +/- 1.2 x 10A10 l/mol, after glucose, Ka: 3.5 +/- 1.2 x 10(10) l/mol. Conversely did glucose feeding increase thyroid hormone stimulated oxygen consumption by approximately 100% and thyroid hormone stimulated glucose uptake by approximately 200%. In conclusion, our results show that glucose feeding 1) increases serum T3 levels, 2) decreases nuclear T3 binding, 3) enhances thyroid hormone stimulated oxygen consumption and glucose uptake.

摘要

评估了葡萄糖喂养对血清甲状腺激素浓度、核 T3 结合以及甲状腺激素刺激的氧消耗和葡萄糖摄取的影响。六名无甲状腺疾病的人连续两天仅喂食葡萄糖（2500 千卡/天）。葡萄糖喂养导致以下血清激素水平（葡萄糖喂养前后）：T3：1.07 对 1.16 nmol/l（p<0.05）；FT4I：76 对 102 a.u.（p<0.05），TSH：1.48 对 1.14 mU/l（无显著差异）。葡萄糖喂养后核 T3 结合减少；之前：最大结合能力（MBC）1.3±0.5 fmol/100μg DNA，葡萄糖喂养后 MBC：0.8±0.2 fmol/100μg DNA（p<0.05）。两组在葡萄糖喂养前的 Ka 相同，Ka：4.2±1.2×10^10 l/mol，葡萄糖喂养后，Ka：3.5±1.2×10^(10) l/mol。相反，葡萄糖喂养使甲状腺激素刺激的氧消耗增加约 100%，甲状腺激素刺激的葡萄糖摄取增加约 200%。总之，我们的结果表明，葡萄糖喂养 1）增加血清 T3 水平，2）降低核 T3 结合，3）增强甲状腺激素刺激的氧消耗和葡萄糖摄取。