遗传漂变与有效种群大小估计。
Genetic drift and estimation of effective population size.
机构信息
Center for Demographic and Population Genetics, University of Texas at Houston, Houston, Texas 77025.
出版信息
Genetics. 1981 Jul;98(3):625-40. doi: 10.1093/genetics/98.3.625.
The statistical properties of the standardized variance of gene frequency changes (a quantity equivalent to Wright's inbreeding coefficient) in a random mating population are studied, and new formulae for estimating the effective population size are developed. The accuracy of the formulae depends on the ratio of sample size to effective size, the number of generations involved (t), and the number of loci or alleles used. It is shown that the standardized variance approximately follows the chi(2) distribution unless t is very large, and the confidence interval of the estimate of effective size can be obtained by using this property. Application of the formulae to data from an isolated population of Dacus oleae has shown that the effective size of this population is about one tenth of the minimum census size, though there was a possibility that the procedure of sampling genes was improper.
研究了随机交配群体中基因频率变化的标准化方差（与 Wright 近交系数相当的数量）的统计性质，并提出了新的估计有效种群大小的公式。公式的准确性取决于样本大小与有效大小的比值、涉及的世代数（t）以及使用的基因座或等位基因数。结果表明，除非 t 非常大，否则标准化方差近似遵循卡方分布，并且可以利用这一特性获得有效大小估计的置信区间。将这些公式应用于来自孤立的橄榄果蝇种群的数据表明，该种群的有效大小约为最小普查大小的十分之一，尽管存在抽样基因的程序可能不正确的可能性。
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