Hartati Hartati, Putra Widya Pintaka Bayu, Handiwirawan Eko, Ramon Erpan, Firison Jhon, Zubir Zubir, Suretno Nandari Dyah, Mariyono Mariyono, Yusriani Yenni, Robba Dewi Khosiya, Destomo Alfian, Anggraeni Tika, Anwar Pajri, Irmawanti Sulistiyoningtiyas, Aprisal Aprisal, Elieser Simon, Kurniawati Dian
Research Center for Animal Husbandry, National Research and Innovation Agency (BRIN), Bogor 16911, Indonesia.
Research Center for Applied Zoology, National Research and Innovation Agency (BRIN), Bogor 16911, Indonesia.
Vet World. 2024 Nov;17(11):2537-2543. doi: 10.14202/vetworld.2024.2537-2543. Epub 2024 Nov 13.
Coat color is a phenotypic trait that is affected by many functional genes. In addition, coat color is an important characteristic of breeds in livestock. This study aimed to determine functional genes for coat color patterns in Sumatran native cattle in Indonesia using a genome-wide association study method.
A bovine single nucleotide polymorphism (SNP) 50K BeadChip was used for the investigation. A total of 46. Sumatran native cattle of three colors as follows: Brown (36 animals), white (9 animals), and black (1 animal), were used as experimental animals.
Results showed that the SNP markers ARS-BFGL-NGS-75486 (p = 2.46 × 10) and BTB-01992588 (p = 1.06 × 10) were selected as two genetic markers for coat color variation in animals under study, which were located at the cytoplasmic FMR1-interacting protein 2 (2) gene at BTA7 and small G protein signaling modulator 1() genes at BTA17, respectively. The polymorphic informative content values of both SNP markers were 0.33 (ARS-BFGL-NGS-75486) and 0.13 (BTB-01992588). In this study, a genetic marker for coat color patterns in Sumatran native cattle was obtained based on the haplotypes of both SNP markers.
It can be concluded that and are two coloration genes that affect the phenotype characteristics of Sumatran native cattle.
毛色是受许多功能基因影响的表型性状。此外，毛色是家畜品种的一个重要特征。本研究旨在使用全基因组关联研究方法确定印度尼西亚苏门答腊本地牛毛色模式的功能基因。
使用牛单核苷酸多态性（SNP）50K芯片进行调查。总共46头苏门答腊本地牛，分为三种毛色：棕色（36头）、白色（9头）和黑色（1头），用作实验动物。
结果表明，SNP标记ARS-BFGL-NGS-75486（p = 2.46 × 10）和BTB-01992588（p = 1.06 × 10）被选为所研究动物毛色变异的两个遗传标记，它们分别位于BTA7上的细胞质FMR1相互作用蛋白2（2）基因和BTA17上的小G蛋白信号调节剂1（）基因。两个SNP标记的多态信息含量值分别为0.33（ARS-BFGL-NGS-75486）和0.13（BTB-01992588）。在本研究中，基于两个SNP标记的单倍型获得了苏门答腊本地牛毛色模式的遗传标记。
可以得出结论，[此处原文可能有误，推测应为两个基因名称]和[此处原文可能有误，推测应为两个基因名称]是影响苏门答腊本地牛表型特征的两个毛色基因。
