铜和钯催化的2-(2',3'-链二烯基)-β-酮酯、有机卤化物和二苄基偶氮二甲酸酯的不对称一锅串联加成-环化反应：一种对映选择性合成吡唑烷衍生物的有效方法。
Cu- and Pd-catalyzed asymmetric one-pot tandem addition-cyclization reaction of 2-(2',3'-alkadienyl)-beta-keto esters, organic halides, and dibenzyl azodicarboxylate: an effective protocol for the enantioselective synthesis of pyrazolidine derivatives.
作者信息
Ma Shengming, Jiao Ning, Zheng Zilong, Ma Zhichao, Lu Zhan, Ye Longwu, Deng Youqian, Chen Guofei
机构信息
State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Lu, Shanghai 200032, P R China.
出版信息
Org Lett. 2004 Jun 24;6(13):2193-6. doi: 10.1021/ol0493498.
[reaction: see text] Optically active pyrazolidine derivatives have been constructed by the Cu- and Pd-catalyzed asymmetric one-pot tandem addition-cyclization reaction of 2-(2',3'-dienyl)-beta-ketoesters, organic halides, and dibenzyl azodicarboxylate. The absolute configurations of the final products depend on the structure of the ligand.
[反应：见正文] 通过2-(2',3'-二烯基)-β-酮酯、有机卤化物和二苄基偶氮二甲酸酯的铜和钯催化不对称一锅串联加成-环化反应构建了光学活性吡唑烷衍生物。最终产物的绝对构型取决于配体的结构。
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