Jacobi Ute, Kaiser Marco, Toll Rani, Mangelsdorf Susanne, Audring Heike, Otberg Nina, Sterry Wolfram, Lademann Juergen
Department of Dermatology, Charité - Universitätsmedizin Berlin, Berlin, Germany.
Skin Res Technol. 2007 Feb;13(1):19-24. doi: 10.1111/j.1600-0846.2006.00179.x.
BACKGROUND/PURPOSE: Porcine ear skin is used in studies of percutaneous penetration as a substitute for human skin. The structure of this tissue, including hair follicles, was studied qualitatively and quantitatively in comparison with human skin.
Sections of shock-frozen biopsies, biopsies embedded in paraffin and cyanoacrylate skin surface biopsies were investigated using microscopy. The thickness of the different skin layers and the follicular characteristics were determined.
The thickness of the stratum corneum was 17-28 microm, whereas the viable epidermis was 60-85 microm thick. On 1 cm(2), 11-25 hairs were detected, showing a diameter of 58-97 microm and a maximal extension depth of 0.96-1.38 mm into the skin. The orifices of the porcine infundibula showed a diameter of approximately 200 microm.
The results obtained are similar to those of human skin, indicating the suitability of this porcine tissue as a model for human skin.
背景/目的：猪耳皮肤在经皮渗透研究中被用作人体皮肤的替代品。对该组织的结构，包括毛囊，进行了定性和定量研究，并与人体皮肤进行比较。
使用显微镜对速冻活检组织切片、石蜡包埋活检组织以及氰基丙烯酸酯皮肤表面活检组织进行研究。测定不同皮肤层的厚度和毛囊特征。
角质层厚度为17 - 28微米，而有活力的表皮厚度为60 - 85微米。在1平方厘米面积上检测到11 - 25根毛发，毛发直径为58 - 97微米，最大深入皮肤深度为0.96 - 1.38毫米。猪漏斗部开口直径约为200微米。
所获得的结果与人体皮肤相似，表明这种猪组织适合作为人体皮肤模型。
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