Yim Susie, Malhotra Atul, Veves Aristidis
Microcirculation Laboratory, Palmer 321A, Beth Israel Deaconess Medical Center, West Campus, One Deaconess Road, Boston, MA, 02215, USA.
Curr Diab Rep. 2007 Feb;7(1):8-13. doi: 10.1007/s11892-007-0003-9.
Diabetes is an oxidative stress disorder as a result of both hyperglycemia and increased levels of free fatty acids. Oxidative stress has been implicated in the pathogenesis of diabetes-related complications, and treatment with antioxidants seemed to be a promising therapeutic option. Although animal studies and preliminary human studies were initially encouraging, subsequent human studies have failed to show a clear benefit of antioxidants, whereas some studies have even suggested that they can be potentially harmful. Therefore, treatment with antioxidants cannot be currently recommended as a therapeutic option.
糖尿病是一种由高血糖和游离脂肪酸水平升高导致的氧化应激紊乱疾病。氧化应激与糖尿病相关并发症的发病机制有关,使用抗氧化剂进行治疗似乎是一种有前景的治疗选择。尽管动物研究和初步的人体研究最初令人鼓舞,但随后的人体研究未能显示出抗氧化剂有明显益处,而一些研究甚至表明它们可能具有潜在危害。因此,目前不推荐将抗氧化剂治疗作为一种治疗选择。