Vorp David A
Department of Surgery, Division of Vascular Surgery, Department of Bioengineering, McGowan Institute for Regenerative Medicine, Center for Vascular Remodeling and Regeneration, University of Pittsburgh, Pittsburgh, PA, USA.
J Biomech. 2007;40(9):1887-902. doi: 10.1016/j.jbiomech.2006.09.003. Epub 2007 Jan 24.
Abdominal aortic aneurysm (AAA) is a condition whereby the terminal aorta permanently dilates to dangerous proportions, risking rupture. The biomechanics of AAA has been studied with great interest since aneurysm rupture is a mechanical failure of the degenerated aortic wall and is a significant cause of death in developed countries. In this review article, the importance of considering the biomechanics of AAA is discussed, and then the history and the state-of-the-art of this field is reviewed--including investigations into the biomechanical behavior of AAA tissues, modeling AAA wall stress and factors which influence it, and the potential clinical utility of these estimates in predicting AAA rupture.
腹主动脉瘤（AAA）是一种终末段主动脉永久性扩张至危险比例并伴有破裂风险的病症。由于动脉瘤破裂是退变主动脉壁的机械性失效且是发达国家的一个重要死因，因此腹主动脉瘤的生物力学一直备受关注。在这篇综述文章中，我们讨论了考虑腹主动脉瘤生物力学的重要性，接着回顾了该领域的历史和现状，包括对腹主动脉瘤组织生物力学行为的研究、腹主动脉瘤壁应力建模及其影响因素，以及这些评估在预测腹主动脉瘤破裂方面的潜在临床应用价值。
