Heuson J C, Longeval E, Leclercq G, Mattheiem W H
J Gynecol Obstet Biol Reprod (Paris). 1975;4 SUPPL 2:207-14.
Tissue samples from 166 primary and 136 metastatic breast cancers were analysed for the presence of estrogen receptors. It was found by measuring the affinity of the cytoplasmic fraction of these samples for 3H-estradiol-17 beta that receptors were present in 72 p. 100 and 54 p. 100 of primary and metastatic cancers respectively. Receptor concentration varied among sample in an apparently continuous distribution from zero to 2,080 femtomoles per mg tissue protein. This suggests that mammary tumors are different from one another more in a quantitative than in a qualitative way. Detectable amounts of receptors were found in samples from mammary dysplasia, fibroadenomas as well as from one papilloma; none was detected in samples from non-tumorous mammary gland, nipple areola or skin. At mastectomy, no correlation was found between presence or absence of receptors in the primary tumors, and presence or absence of metastatic axillary nodes. On the other hand both the primary and its axillary metastases almost always displayed the same characteristic as far as presence or absence of receptors was concerned. Analysis of clinical studies reported seems to indicate that women with advanced breast cancer respond in a fair proportion of cases to various endocrine treatments when tumor tissue biopsies contain estrogen receptors whereas the probability of a response is very low in their absence.
对166例原发性乳腺癌和136例转移性乳腺癌的组织样本进行雌激素受体检测。通过测量这些样本细胞质部分对3H-雌二醇-17β的亲和力发现，原发性和转移性癌症中分别有72%和54%存在受体。受体浓度在样本中呈明显的连续分布，从零到每毫克组织蛋白2080飞摩尔不等。这表明乳腺肿瘤之间的差异更多地体现在数量上而非质量上。在乳腺发育异常、纤维腺瘤以及一例乳头状瘤的样本中发现了可检测到的受体量；在非肿瘤性乳腺、乳头乳晕或皮肤的样本中未检测到。在乳房切除术中，原发性肿瘤中受体的有无与腋窝转移性淋巴结的有无之间未发现相关性。另一方面，就受体的有无而言，原发性肿瘤及其腋窝转移灶几乎总是表现出相同的特征。对所报道临床研究的分析似乎表明，当肿瘤组织活检含有雌激素受体时，晚期乳腺癌女性患者在相当比例的病例中对各种内分泌治疗有反应，而在没有受体的情况下，反应的可能性非常低。
