Bird C E, Houghton B, Westenbrink W, Tenniswood M, Sterns E E, Clark A F
Can Med Assoc J. 1981 Apr 15;124(8):1010-2.
The presence or absence of a specific estradiol-binding protein receptor in the cytoplasm of primary and secondary tumour cells has been used by physicians as an important guide in deciding whether to use hormonal therapy for patients with metastatic breast cancer. This report gives the levels of estradiol receptors in the cytosol of 228 primary and secondary breast tumours, measured by a sensitive multiple-point assay in which dextran-coated charcoal separated bound form unbound estrogen. The data were analysed with a Scatchard plot. Of the 175 primary and 53 secondary tumours 53% and 32% respectively gave positive results. The mean receptor level in the primary tumours was significantly higher among older patients and increased with age. With metastatic lesions positive results were more common in lymph node samples tha in skin nodule samples.
原发性和继发性肿瘤细胞胞质中特定雌二醇结合蛋白受体的有无，已被医生用作决定是否对转移性乳腺癌患者采用激素疗法的重要依据。本报告给出了228例原发性和继发性乳腺肿瘤细胞溶质中雌二醇受体的水平，该水平通过一种灵敏的多点测定法测得，在该方法中，葡聚糖包被的活性炭将结合态雌激素与游离态雌激素分离。数据用Scatchard图进行分析。在175例原发性肿瘤和53例继发性肿瘤中，分别有53%和32%的结果呈阳性。原发性肿瘤中，老年患者的平均受体水平显著更高，且随年龄增长而升高。对于转移性病变，淋巴结样本的阳性结果比皮肤结节样本更常见。
