O'Reilly Philip, Bailey William
Division of Pulmonary and Critical Care Medicine, University of Alabama at Birmingham, USA.
Curr Opin Pulm Med. 2007 Mar;13(2):120-4. doi: 10.1097/MCP.0b013e32802c7cfe.
Long-term oxygen treatment is one of the few interventions that improve survival in chronic obstructive pulmonary disease and it is widely used even though published evidence supporting the use of this treatment in chronic obstructive pulmonary disease is scanty. In addition, some studies do not demonstrate a mortality benefit for long-term oxygen treatment in this disease. It is important that long-term oxygen treatment be administered only to those patients who will benefit and in a manner that maximizes its efficacy. New studies are urgently needed to address these questions.
The published evidence for and against the use of long-term oxygen treatment in chronic obstructive pulmonary disease is summarized and problems with current guidelines and important areas for future research are discussed.
Future research will address the optimal timing and duration of oxygen therapy during rest, exercise and sleep, ways of identifying chronic obstructive pulmonary disease patients who are most likely to benefit and ways of improving patient compliance, all of which may have a profound effect on clinical practice.
长期氧疗是少数能提高慢性阻塞性肺疾病患者生存率的干预措施之一，尽管支持在慢性阻塞性肺疾病中使用该疗法的已发表证据很少，但仍被广泛应用。此外，一些研究并未证明长期氧疗对该疾病有降低死亡率的益处。重要的是，长期氧疗应仅给予那些将从中受益的患者，并以使其疗效最大化的方式进行。迫切需要新的研究来解决这些问题。
总结了关于在慢性阻塞性肺疾病中支持和反对使用长期氧疗的已发表证据，并讨论了当前指南存在的问题以及未来研究的重要领域。
未来的研究将探讨在休息、运动和睡眠期间氧疗的最佳时机和持续时间，识别最可能受益的慢性阻塞性肺疾病患者的方法，以及提高患者依从性的方法，所有这些都可能对临床实践产生深远影响。
