Leroux Caroline, Girard Nicolas, Cottin Vincent, Greenland Timothy, Mornex Jean-François, Archer Fabienne
Université de Lyon 1, INRA, UMR754, Ecole Nationale Vétérinaire de Lyon, IFR 128, F-69007, Lyon, France.
Vet Res. 2007 Mar-Apr;38(2):211-28. doi: 10.1051/vetres:2006060. Epub 2007 Jan 25.
Jaagsiekte Sheep Retrovirus (JSRV) is a betaretrovirus infecting sheep. This virus is responsible for a pulmonary adenocarcinoma, by transformation of epithelial cells from the bronchioli and alveoli. This animal cancer is similar to human bronchioloalveolar cancer (BAC), a specific form of human lung cancer for which a viral aetiology has not yet been identified. JSRV interacts with target cells through the membrane receptor Hyal2. The JSRV genome is simple and contains no recognised oncogene. It is now well established that the viral envelope protein is oncogenic by itself, via the cytoplasmic domain of the transmembrane glycoprotein and some domains of the surface glycoprotein. Activation of the PI3K/Akt and MAPK pathways participates in the envelope-induced transformation. Tumour development is associated with telomerase activation. This review will focus on the induction of cancer by JSRV.
绵羊肺腺瘤逆转录病毒（JSRV）是一种感染绵羊的β逆转录病毒。这种病毒通过使细支气管和肺泡的上皮细胞发生转化，导致肺腺癌。这种动物癌症与人类细支气管肺泡癌（BAC）相似，BAC是一种尚未确定病毒病因的人类肺癌特殊形式。JSRV通过膜受体Hyal2与靶细胞相互作用。JSRV基因组简单，不包含公认的癌基因。现在已经明确，病毒包膜蛋白本身具有致癌性，通过跨膜糖蛋白的胞质结构域和表面糖蛋白的一些结构域发挥作用。PI3K/Akt和MAPK信号通路的激活参与了包膜诱导的转化过程。肿瘤发展与端粒酶激活有关。本综述将聚焦于JSRV诱导癌症的相关内容。
