Healy Declan A, Hayes Conor J, Leonard Paul, McKenna Louise, O'Kennedy Richard
School of Biotechnology and Biomedical Diagnostics Institute, National Centre for Sensor Research, Dublin City University, Dublin 9, Ireland.
Trends Biotechnol. 2007 Mar;25(3):125-31. doi: 10.1016/j.tibtech.2007.01.004. Epub 2007 Jan 24.
Prostate-specific antigen (PSA) is the best serum marker currently available for the detection of prostate cancer and is the forensic marker of choice for determining the presence of azoospermic semen in some sexual assault cases. Most current assays for PSA detection are processed on large analyzers at dedicated testing sites, which require that samples be sent away for testing. This leads to delays in patient management and increased administration costs. The recent emphasis placed on the need for point-of-care patient management has led to the development of novel biosensor detection strategies that are suitable for the miniaturization of assays for various targets including PSA. This review highlights the current and novel analytical technologies used for PSA detection, which will benefit clinicians, patients and forensic workers in the future.
前列腺特异性抗原（PSA）是目前可用于检测前列腺癌的最佳血清标志物，也是某些性侵犯案件中确定无精子精液是否存在的首选法医标志物。目前大多数用于PSA检测的分析方法是在专门检测地点的大型分析仪上进行的，这要求将样本送去检测。这导致患者管理延迟和管理成本增加。最近对即时护理患者管理需求的强调促使了新型生物传感器检测策略的发展，这些策略适用于包括PSA在内的各种目标分析方法的小型化。本综述重点介绍了目前用于PSA检测的以及新型分析技术，这将在未来使临床医生、患者和法医工作者受益。
