Future Industries Institute, University of South Australia, Mawson Lakes Campus, Adelaide, SA 5000, Australia.
Molecules. 2022 Nov 17;27(22):7952. doi: 10.3390/molecules27227952.
Metal-oxide semiconducting materials are promising for building high-performance field-effect transistor (FET) based biochemical sensors. The existence of well-established top-down scalable manufacturing processes enables the reliable production of cost-effective yet high-performance sensors, two key considerations toward the translation of such devices in real-life applications. Metal-oxide semiconductor FET biochemical sensors are especially well-suited to the development of Point-of-Care testing (PoCT) devices, as illustrated by the rapidly growing body of reports in the field. Yet, metal-oxide semiconductor FET sensors remain confined to date, mainly in academia. Toward accelerating the real-life translation of this exciting technology, we review the current literature and discuss the critical features underpinning the successful development of metal-oxide semiconductor FET-based PoCT devices that meet the stringent performance, manufacturing, and regulatory requirements of PoCT.
金属氧化物半导体材料在构建高性能场效应晶体管（FET）基生化传感器方面具有广阔的应用前景。成熟的自上而下的可扩展制造工艺的存在使得能够可靠地生产具有成本效益但性能优异的传感器，这是此类器件在实际应用中转化的两个关键考虑因素。金属氧化物半导体 FET 生化传感器特别适合开发即时检测（PoCT）设备，这一点在该领域快速增长的报告中得到了充分体现。然而，金属氧化物半导体 FET 传感器迄今为止仍然主要局限于学术界。为了加速这项令人兴奋的技术在现实生活中的应用，我们回顾了当前的文献，并讨论了支持成功开发基于金属氧化物半导体 FET 的 PoCT 设备的关键特征，这些设备满足 PoCT 的严格性能、制造和监管要求。
