Shah N, Mehra A
Department of Chemical Engineering, Indian Institute of Technology, Bombay, India.
ASAIO J. 1996 May-Jun;42(3):181-9.
The use of perfluorocarbons emulsified in water as blood substitutes (artificial blood), is well known. Although considerable research has been devoted to the study of stability, toxicity, and gas solubility properties of these emulsions, there is no quantitative guide to the oxygen transport behavior in such emulsions, especially with reference to this transport process in actual blood. This paper describes a mathematical model from which the oxygen flux into a straight, cylindrical tube carrying a perfluorocarbon emulsion may be computed. The solutions to the proposed model can be adapted to that for a capillary or for a single tube in a blood oxygenator. The rates of oxygen transfer, so obtained, have been compared with analogous transfer rates that can be achieved in natural blood flowing under identical conditions. Therefore, the minimal solubilization capacity for oxygen required of a perfluorocarbon emulsion can be estimated on a quantitative basis. The modeling approach used in this study is based on the well tested theory of mass transfer in microheterogeneous media reported in the chemical engineering literature.
使用在水中乳化的全氟化碳作为血液替代品（人造血液）是众所周知的。尽管已经对这些乳液的稳定性、毒性和气溶性进行了大量研究，但对于此类乳液中的氧传输行为，尤其是相对于实际血液中的这种传输过程，尚无定量指导。本文描述了一个数学模型，通过该模型可以计算进入携带全氟化碳乳液的直管中的氧通量。所提出模型的解可以适用于毛细血管或血液氧合器中的单根管子的情况。如此获得的氧传输速率已与在相同条件下流动的天然血液中可实现的类似传输速率进行了比较。因此，可以在定量基础上估计全氟化碳乳液所需的最小氧溶解能力。本研究中使用的建模方法基于化学工程文献中报道的经过充分测试的微非均相介质中的传质理论。
