醋酸氟轻松（Retisert）植入术后的巨细胞病毒性视网膜炎。
Cytomegalovirus retinitis after fluocinolone acetonide (Retisert) implant.
作者信息
Ufret-Vincenty Rafael L, Singh Rishi P, Lowder Careen Y, Kaiser Peter K
机构信息
Cleveland Clinic Cole Eye Institute, Cleveland, Ohio 44195, USA.
出版信息
Am J Ophthalmol. 2007 Feb;143(2):334-5. doi: 10.1016/j.ajo.2006.09.020. Epub 2006 Oct 23.
PURPOSE
To report a case of cytomegalovirus (CMV) retinitis after placement of a fluocinolone acetonide (Retisert) implant.
DESIGN
Interventional case report.
METHODS
Retrospective chart review.
RESULTS
A 65-year-old man with a history of Adamantiades-Behcet disease and bilateral recurrent uveitis that was unresponsive to systemic corticosteroid-sparing immunosuppressive therapy developed clinical evidence of CMV retinitis after receiving his second intravitreal Retisert implant in the left eye, while on no systemic immunosuppression. He did not develop CMV retinitis in the right eye despite multiple intraocular and periocular steroid injections. The patient responded well to intravitreal foscarnet followed by placement of an intravitreal ganciclovir implant.
CONCLUSIONS
Ophthalmologists should be aware of the potential risk for development of CMV retinitis after local ocular immunosuppressive therapy.
目的
报告一例在植入醋酸氟轻松（Retisert）植入物后发生巨细胞病毒（CMV）视网膜炎的病例。
设计
介入性病例报告。
方法
回顾性病历审查。
结果
一名65岁男性，有阿达姆antides - 贝赫切特病病史及双侧复发性葡萄膜炎，对全身性糖皮质激素节省免疫抑制治疗无反应，在左眼接受第二次玻璃体内Retisert植入物后，在未进行全身性免疫抑制的情况下出现了CMV视网膜炎的临床证据。尽管右眼多次接受眼内和眼周类固醇注射，但未发生CMV视网膜炎。患者对玻璃体内膦甲酸治疗反应良好，随后植入了玻璃体内更昔洛韦植入物。
结论
眼科医生应意识到局部眼部免疫抑制治疗后发生CMV视网膜炎的潜在风险。
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