氟轻松醋酸酯植入物（Retisert）治疗两例 AIDS 合并巨细胞病毒性视网膜炎病史的慢性囊样黄斑水肿患者。
Fluocinolone acetonide implant (Retisert) for chronic cystoid macular edema in two patients with AIDS and a history of cytomegalovirus retinitis.
机构信息
University of California, San Francisco, Department of Ophthalmology, San Francisco, California 94143-0730, USA.
出版信息
Ocul Immunol Inflamm. 2011 Jun;19(3):206-9. doi: 10.3109/09273948.2010.538120.
PURPOSE
To report the authors' experience using fluocinolone acetonide (Retisert) to treat cystoid macular edema (CME) resulting from immune recovery uveitis (IRU) in 2 acquired immunodeficiency syndrome (AIDS) patients with a history of cytomegalovirus (CMV) retinitis.
DESIGN
Interventional case series.
METHODS
Medical records were reviewed of 2 patients who received Retisert implantation in 3 eyes for IRU-associated inflammation and CME. Suppression of CMV disease was achieved with oral medication in one patient and with simultaneous implantation of a ganciclovir implant in the other patient.
RESULTS
After Retisert implantation in 3 eyes in AIDS patients on HAART, improvement in CME was seen in 2 eyes. No CMV reactivation was detected during the several-month follow-up period.
CONCLUSIONS
Retisert may be an effective treatment for CME in AIDS patients with IRU reactivation and a history of CMV retinitis.
目的
报告作者使用氟轻松 acetonide（Retisert）治疗 2 例获得性免疫缺陷综合征（AIDS）患者因免疫恢复性葡萄膜炎（IRU）导致的囊样黄斑水肿（CME）的经验，这些患者均有巨细胞病毒（CMV）视网膜炎病史。
设计
介入性病例系列研究。
方法
回顾了 2 例接受 Retisert 植入术治疗 3 只眼 IRU 相关炎症和 CME 的患者的病历。1 例患者通过口服药物抑制 CMV 疾病，另 1 例患者同时植入更昔洛韦植入物。
结果
在接受 HAART 的 AIDS 患者的 3 只眼中植入 Retisert 后，2 只眼中的 CME 得到改善。在数月的随访期间，未发现 CMV 再激活。
结论
Retisert 可能是治疗 AIDS 患者 IRU 再激活和 CMV 视网膜炎病史的 CME 的有效治疗方法。
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