Bizzini Alain, Majcherczyk Paul, Beggah-Möller Siham, Soldo Blazenka, Entenza José M, Gaillard Muriel, Moreillon Philippe, Lazarevic Vladimir
Département de Microbiologie Fondamentale, Bâtiment Biophore, Université de Lausanne, Quartier UNIL-Sorge, CH-1015 Lausanne, Switzerland.
Microbiology (Reading). 2007 Feb;153(Pt 2):490-498. doi: 10.1099/mic.0.29256-0.
Streptococcus gordonii alpha-phosphoglucomutase, which converts glucose 6-phosphate to glucose 1-phosphate, is encoded by pgm. The pgm transcript is monocistronic and is initiated from a sigma(A)-like promoter. Mutants with a gene disruption in pgm exhibited an altered cell wall muropeptide pattern and a lower teichoic acid content, and had reduced fitness both in vitro and in vivo. In vitro, the reduced fitness included reduced growth, reduced viability in the stationary phase and increased autolytic activity. In vivo, the pgm-deficient strain had a lower virulence in a rat model of experimental endocarditis.
戈登氏链球菌α-磷酸葡萄糖变位酶可将6-磷酸葡萄糖转化为1-磷酸葡萄糖，由pgm编码。pgm转录本是单顺反子的，由一个类σ(A)启动子起始转录。pgm基因发生破坏的突变体表现出细胞壁肽聚糖模式改变、磷壁酸含量降低，并且在体外和体内的适应性均降低。在体外，适应性降低包括生长减慢、稳定期活力降低以及自溶活性增加。在体内，pgm缺陷菌株在实验性心内膜炎大鼠模型中的毒力较低。
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