Mi C
Department of Pathology, Chongqing University of Medical Sciences.
Zhonghua Bing Li Xue Za Zhi. 1991 Dec;20(4):296-8.
The clinicopathologic, ultrastructural, and immunohistochemical features of six cases of extraskeletal myxoid chondrosarcoma are described. Light microscopic examination disclosed a lobulated neoplasm consisting of cells that tended to be round or polygonal with plenty of eosinophilic cytoplasm. The tumor cells were arranged in strands and small nests surrounded by abundant myxoid extracellular matrix. Ultrastructurally, these tumor cells displayed the signs of chondroblastic differentiation. The cytoplasm contained numerous rough endoplasmic reticulum, mitochondria and scattered glycogen granules. The intercellular matrix showed amorphous material and electronic dense and fine granules. The tumor cells in all these six cases showed diffuse immunostaining for S-100 protein but were negative for keratin. The data obtained tend to support the chondroblastic origin of this tumor.
描述了6例骨外黏液样软骨肉瘤的临床病理、超微结构及免疫组化特征。光镜检查显示肿瘤呈分叶状，由圆形或多边形细胞组成，胞质丰富，嗜酸性。肿瘤细胞呈条索状和小巢状排列，周围有丰富的黏液样细胞外基质。超微结构上，这些肿瘤细胞显示出软骨母细胞分化的迹象。胞质内含有大量粗面内质网、线粒体及散在的糖原颗粒。细胞间基质显示无定形物质以及电子致密和细颗粒。所有这6例肿瘤细胞均显示S-100蛋白弥漫性免疫染色阳性，但角蛋白染色阴性。所获得的数据倾向于支持该肿瘤起源于软骨母细胞。
