Li X Q, Li X W, Zhu C X
Institute of Combined Traditional Chinese and Western Medicine, Hunan Medical University, Changsha.
Zhong Xi Yi Jie He Za Zhi. 1991 Nov;11(11):647-50, 643.
In order to study the connection of diastolic activity of smooth muscles of blood vessels with development of hypertension, plasma cAMP, cGMP, TXB2, 6-K-PGF1 alpha, ANP, SP were determined with radioimmunoassay, of 173 hypertension patients with Liver Yang exuberance (LYE) 91 cases, and Yin deficiency and Yang exuberance (YDYE) 82 cases. In addition, 228 health subjects served as control. The results showed that the levels of cAMP, cGMP and TXB2 in both LYE and YDYE groups were higher than those in the control group, but the levels of ANP, SP and cAMP/cGMP ratio in LYE and YDYE groups were lower than those in the control. As to the level of 6-K-PGF1 alpha, no significant variance was found between these groups. After TCM-WM treatment, the levels of cAMP, cGMP and TXB2 in LYE and YDYE groups got down, as compared with those in the control, adversely the levels of ANP, SP and 6-K-PGF1 alpha in LYE and YDYE groups turned up significantly. However the cAMP/cGMP ratio had no remarkable change between these groups. The linear regression analyses between the diastolic pressure and ANP or SP both proved negative correlation (r = -0.36, P less than 0.05; r = -0.35, P less than 0.05). The findings indicated that the TCM-WM treatment was the most effective among the therapies employed in the study, and that this therapy affected the diastolic activity of smooth muscles by modulating the above factors existing in the nervous and endocrine systems of the patients with hypertension.
为研究血管平滑肌舒张活动与高血压发病的关系，采用放射免疫法测定了173例高血压患者血浆中环磷酸腺苷（cAMP）、环磷酸鸟苷（cGMP）、血栓素B2（TXB2）、6-酮-前列腺素F1α（6-K-PGF1α）、心钠素（ANP）、P物质（SP）水平，其中肝阳上亢型（LYE）91例，阴虚阳亢型（YDYE）82例。另外，选取228名健康受试者作为对照。结果显示，LYE组和YDYE组的cAMP、cGMP及TXB2水平均高于对照组，但LYE组和YDYE组的ANP、SP水平及cAMP/cGMP比值均低于对照组。至于6-K-PGF1α水平，各组间无显著差异。中西医结合治疗后，LYE组和YDYE组的cAMP、cGMP及TXB2水平与对照组相比下降，而LYE组和YDYE组的ANP、SP及6-K-PGF1α水平则显著升高。然而，各组间cAMP/cGMP比值无明显变化。舒张压与ANP或SP的线性回归分析均显示呈负相关（r = -0.36，P＜0.05；r = -0.35，P＜0.05）。研究结果表明，中西医结合治疗是本研究中最有效的治疗方法，该疗法通过调节高血压患者神经内分泌系统中存在的上述因素来影响平滑肌的舒张活动。
