He J, Wang C, Xu J
302 Hospital of PLA, Beijing.
Zhong Xi Yi Jie He Za Zhi. 1990 Feb;10(2):75-7, 67.
Plasma of cAMP and cGMP in 30 cases of chronic active hepatitis (group of cholestatic patients) as well as in 20 cases of chronic hepatitis with submassive or massive necrosis (group of chronic severe hepatitis patients) were studied with 125I-marked radioimmunoassay. 50 cases with their serum bilirubin levels higher than 171 mumol/L were selected as subjects for this study. Among them, 42 were diagnosed as hepatitis B, 6 as coinfection of hepatitis A and B. According to differentiation of symptoms and signs of TCM, 24 were diagnosed as simple hepatitis due to blood stasis and blood heat, 17 as hepatitis due to blood stasis and blood heat accompanying symptoms of Yang deficiency of the Spleen and Kidney. 20 healthy persons were selected as controls. The results were as follows: cAMP was 56.82 +/- 25.54 ng/L and 80.32 +/- 20.73 ng/L, and cGMP was 9.07 +/- 6.56 ng/L and 19.49 +/- 9.34 ng/L in the group of cholestatic patients and in the group of chronic severe hepatitis patients respectively. Both were higher than those in the control group whose cAMP was 14.12 +/- 3.25 ng/L and cGMP was 5.87 +/- 1.44 ng/L (P less than 0.01). Increase in cGMP and decrease in the ratio of cAMP and cGMP in the cases accompanying symptoms of Yang deficiency of the Spleen and Kidney were much higher than those in the other two types of hepatitis patients (P less than 0.01 and 0.05).(ABSTRACT TRUNCATED AT 250 WORDS)
采用¹²⁵I标记放射免疫分析法，对30例慢性活动性肝炎（胆汁淤积型患者组）及20例亚大块或大块坏死性慢性肝炎（慢性重型肝炎患者组）患者的血浆环磷腺苷（cAMP）和环磷鸟苷（cGMP）进行了研究。选取50例血清胆红素水平高于171μmol/L的患者作为本研究对象。其中，42例诊断为乙型肝炎，6例为甲型和乙型肝炎合并感染。根据中医症状和体征辨证，24例诊断为单纯血瘀血热型肝炎，17例为血瘀血热兼脾肾阳虚型肝炎。选取20名健康人作为对照。结果如下：胆汁淤积型患者组和慢性重型肝炎患者组的cAMP分别为56.82±25.54ng/L和80.32±20.73ng/L，cGMP分别为9.07±6.56ng/L和19.49±9.34ng/L。两者均高于对照组，对照组的cAMP为14.12±3.25ng/L，cGMP为5.87±1.44ng/L（P＜0.01）。脾肾阳虚型肝炎患者的cGMP升高及cAMP与cGMP比值降低的幅度，均明显高于其他两型肝炎患者（P＜0.01和0.05）。（摘要截于250字）
