柳叶木兰的生物活性成分：大鼠肥大细胞诱导组胺释放的抑制剂。

Biologically active constituents of Magnolia salicifolia: inhibitors of induced histamine release from rat mast cells.

作者信息

Tsuruga T, Ebizuka Y, Nakajima J, Chun Y T, Noguchi H, Iitaka Y, Sankawa U

机构信息

Faculty of Pharmaceutical Sciences, University of Tokyo, Japan.

出版信息

Chem Pharm Bull (Tokyo). 1991 Dec;39(12):3265-71. doi: 10.1248/cpb.39.3265.

DOI:10.1248/cpb.39.3265

PMID:1726074

Abstract

The extracts of the flower buds of Magnolia salicifolia showed remarkable anti-allergy effects in passive cutaneous anaphylaxis (PCA) test. The bioactive constituents of this medicinal drug were isolated by monitoring their activities with an in vitro bioassay system measuring inhibitory effects on induced histamine release from rat mast cells. Of the ten isolated compounds magnosalicin is a new compound of neolignan structure. In addition to the isolated compounds samples of coumarins and lignans were evaluated their biological activities with the in vitro bioassay.

摘要

柳叶木兰花蕾提取物在被动皮肤过敏反应（PCA）试验中显示出显著的抗过敏作用。通过使用体外生物测定系统监测其活性，该药物的生物活性成分得以分离，该系统用于测量对大鼠肥大细胞诱导组胺释放的抑制作用。在分离出的十种化合物中，柳叶木兰素是一种新的新木脂素结构化合物。除了分离出的化合物外，还使用体外生物测定法对香豆素和木脂素样品的生物活性进行了评估。