Wu J B, Chun Y T, Ebizuka Y, Sankawa U
Faculty of Pharmaceutical Sciences, University of Tokyo, Japan.
Chem Pharm Bull (Tokyo). 1991 Dec;39(12):3272-5. doi: 10.1248/cpb.39.3272.
Ether, methanol and aqueous extracts of Centipeda minima (Compositae) herbs were found to have significant anti-allergy activities in passive cutaneous anaphylaxis (PCA) test. Three flavonoids, two sesquiterpene lactones and an amide were isolated from this plant material as inhibitors to induced histamine release from mast cells. The sesquiterpenes were identified as isobutyroylplenolin and senecioylplenolin by spectral investigations. The flavonoids and sesquiterpenes exhibited significant anti-allergy activity in PCA test with p.o. administration.
在被动皮肤过敏反应（PCA）试验中，发现石胡荽（菊科）全草的乙醚、甲醇及水提取物具有显著的抗过敏活性。从该植物材料中分离出三种黄酮类化合物、两种倍半萜内酯和一种酰胺，作为肥大细胞诱导组胺释放的抑制剂。通过光谱研究，确定倍半萜为异丁酰基蒲勒醇和千里光酰基蒲勒醇。黄酮类化合物和倍半萜内酯经口服给药在PCA试验中表现出显著的抗过敏活性。
