Shi Wendong, Feng Xi-Qiao, Gao Huajian
Department of Engineering Mechanics, Tsinghua University, Beijing 100084, P. R. China.
Mol Cell Biomech. 2006 Sep;3(3):121-5.
When pulling a vesicle adhered on a substrate, both the force-displacement profile and the maximum force at pull-off are sensitively dependent upon the substrate shape. Here we consider the adhesion between a two-dimensional vesicle and a rigid substrate via long-range molecular interactions. For a given contact area, the theoretical pull-off force of the vesicle is obtained by multiplying the theoretical strength of adhesion and the contact area. It is shown that one may design an optimal substrate shape to achieve the theoretical pull-off force.
当牵拉附着在基底上的囊泡时，力-位移曲线以及拉脱时的最大力都对基底形状敏感地依赖。在此，我们考虑通过长程分子相互作用的二维囊泡与刚性基底之间的粘附。对于给定的接触面积，囊泡的理论拉脱力通过将理论粘附强度与接触面积相乘得到。结果表明，可以设计一种最优的基底形状以实现理论拉脱力。
