Department of Mechanical Engineering, University of Houston, N207 Engineering Bldg 14726 Calhoun Rd, Houston, TX, USA.
Biomech Model Mechanobiol. 2018 Feb;17(1):103-109. doi: 10.1007/s10237-017-0947-x. Epub 2017 Aug 20.
Adhesion plays an integral role in diverse biological functions ranging from cellular transport to tissue development. Estimation of adhesion strength, therefore, becomes important to gain biophysical insight into these phenomena. In this study, we use curvature elasticity to present non-intuitive, yet remarkably simple, universal relationships that capture vesicle-substrate interactions. These relationships not only provide efficient strategies to tease out adhesion energy of biological molecules but can also be used to characterize the physical properties of elastic biomimetic nanoparticles. We validate the modeling predictions with experimental data from two previous studies.
黏附在从细胞运输到组织发育等多种生物功能中起着不可或缺的作用。因此，估计黏附强度对于深入了解这些现象的生物物理特性非常重要。在这项研究中，我们使用曲率弹性来呈现非直观但非常简单的通用关系，以捕捉囊泡-基底相互作用。这些关系不仅提供了有效策略来提取生物分子的黏附能，还可以用于表征弹性仿生纳米颗粒的物理特性。我们用来自之前两项研究的实验数据验证了模型预测。
