Chohedri Abdul-Hameed, Matin Masood, Khosravi Abbas
Department of Anesthesiology, Nemazee Hospital, Shiraz University of Medical Sciences, Iran.
Middle East J Anaesthesiol. 2006 Oct;18(6):1147-56.
BACKGROUND/AIM: Adequate control of postoperative (postop.) nausea, vomiting, dizziness and thirst, and early return to normal activity are important anesthetic goals in the context of ambulatory surgery. This study, investigated the impact of different preoperative fluid therapies or regimens on preventing postop. nausea, vomiting, dizziness and thirst.
In a prospective randomized double-blind study, from June 2002 to November 2003, two hundred ASA grade I-II ambulatory surgical patients received 20 ml/kg of intravenous isotonic electrolyte solution (0.9% sodium chloride) (group A) or 2 ml/kg of same (group B) (n = 100 in each group), over 30 minutes before induction of anesthesia. A standard general anesthetic technique and postop. analgesia were used throughout the operation. Adverse postop. outcomes (nausea, vomiting, dizziness, and thirst) were assessed at 30 and 60 minutes postop. and at discharge.
The incidence of postop. vomiting and thirst significantly decreased in group A compared to group B (p = 0.014 and p = 0.029, respectively). There was no difference in the incidence of nausea and dizziness between the two groups.
We conclude that preoperative high dose hydration (20 ml/kg bolus) can efficiently decrease the incidence of postop. thirst and vomiting within the first 60 minutes, it was superior to low dose hydration and therefore, we recommend it in ambulatory surgeries.
背景/目的：在门诊手术中，充分控制术后恶心、呕吐、头晕和口渴，并尽早恢复正常活动是重要的麻醉目标。本研究调查了不同的术前液体治疗或方案对预防术后恶心、呕吐、头晕和口渴的影响。
在一项前瞻性随机双盲研究中，2002年6月至2003年11月期间，200例ASA I-II级门诊手术患者在麻醉诱导前30分钟内接受20 ml/kg静脉等渗电解质溶液（0.9%氯化钠）（A组）或2 ml/kg相同溶液（B组）（每组n = 100）。整个手术过程采用标准的全身麻醉技术和术后镇痛。在术后30分钟、60分钟和出院时评估术后不良结局（恶心、呕吐、头晕和口渴）。
与B组相比，A组术后呕吐和口渴的发生率显著降低（分别为p = 0.014和p = 0.029）。两组恶心和头晕的发生率没有差异。
我们得出结论，术前高剂量补液（20 ml/kg推注）可有效降低术后60分钟内口渴和呕吐的发生率，优于低剂量补液，因此，我们建议在门诊手术中使用。
