Yogendran S, Asokumar B, Cheng D C, Chung F
Department of Anaesthesia, University of Toronto, Ontario, Canada.
Anesth Analg. 1995 Apr;80(4):682-6. doi: 10.1097/00000539-199504000-00006.
This study investigated the impact of perioperative fluid status on adverse clinical outcomes in ambulatory surgery. Two hundred ASA grade I-III ambulatory surgical patients were prospectively randomized into two groups to receive high (20 mL/kg) or low (2 mL/kg) infusions of isotonic electrolyte solution over 30 min preoperatively. A standardized balanced anesthetic was used. A minimal amount of fluid was given during the intraoperative and postoperative periods. Adverse outcomes were assessed by an investigator blinded to the fluid treatment group at 30 and 60 min after surgery, at discharge, and the first postoperative day. The incidence of thirst, drowsiness, and dizziness was significantly lower in the high-infusion group at all intervals. We recommend perioperative hydration of 20 mL/kg for patients undergoing general anesthesia for short ambulatory surgery.
本研究调查了围手术期液体状态对门诊手术不良临床结局的影响。200例美国麻醉医师协会（ASA）I-III级门诊手术患者被前瞻性随机分为两组，在术前30分钟接受高剂量（20 mL/kg）或低剂量（2 mL/kg）的等渗电解质溶液输注。采用标准化的平衡麻醉。术中和术后给予最少的液体量。由对液体治疗组不知情的研究者在术后30分钟和60分钟、出院时以及术后第一天评估不良结局。在所有时间点，高剂量输注组的口渴、嗜睡和头晕发生率均显著较低。我们建议，对于接受短时间门诊手术全身麻醉的患者，围手术期补液量为20 mL/kg。
